Trivandrum

HLL Lifecare Limited, a Mini Ratna Central Public Sector Enterprise under the Ministry of Health & Family Welfare, Govt. of India is a global provider of high quality healthcare products & services.  With state-of-the-art manufacturing facilities spanning across India, HLL is diversifying into vaccine manufacturing, lifecare services, sanitary napkins besides engaging in procurement consultancy, healthcare, infrastructure development and facility management.

HLL Lifecare Limited, a Mini Ratna Central Public Sector Enterprise under the Ministry of Health & Family Welfare, Govt. of India is a global provider of high quality healthcare products & services.  With state-of-the-art manufacturing facilities spanning across India, HLL is diversifying into vaccine manufacturing, lifecare services, sanitary napkins besides engaging in procurement consultancy, healthcare infrastructure development and facility management.

HLL Lifecare Limited, a Mini Ratna Central Public Sector Enterprise under the Ministry of Health & Family Welfare, Govt. of India is a global provider of high quality healthcare products & services.  With state-of-the-art manufacturing facilities spanning across India, HLL is diversifying into vaccine manufacturing, lifecare services, sanitary napkins besides engaging in procurement consultancy, healthcare infrastructure development and facility management.

HLL Lifecare Limited, a Mini Ratna Central Public Sector Enterprise under the Ministry of Health & Family Welfare, Govt. of India is a global provider of high quality healthcare products & services.  With state-of-the-art manufacturing facilities spanning across India, HLL is diversifying into vaccine manufacturing, lifecare services, sanitary napkins besides engaging in procurement consultancy, healthcare infrastructure development and facility management.

HLL Lifecare Limited, a Mini Ratna Central Public Sector Enterprise under the Ministry of Health & Family Welfare, Govt. of India is a global provider of high quality healthcare products & services.  With state-of-the-art manufacturing facilities spanning across India, HLL is diversifying into vaccine manufacturing, lifecare services, sanitary napkins besides engaging in procurement consultancy, healthcare infrastructure development and facility management.

HLL Lifecare Limited is a Mini Ratna Company of Govt. of India under the Ministry of Health & Family Welfare. HLL, a schedule B Public Sector Enterprise is today a multi product, multi unit organization addressing various public health challenges. The company with five manufacturing units and marketing offices throughout the country is engaged in the manufacturing and marketing of a wide range of contraceptives and healthcare products.

About Authors:
Neethu.R.R
Uthradam
Kannayamkodu
Chenkikunnu
Kilimanoor.P.O, Trivandrum dist, Kerala 695601
neethalekshmi87@gmail.com

Abstract:
Budesonide is a corticosteroid, used in the treatment of inflammatory conditions such as asthma and COPD. The present study was undertaken with the aim to formulate and evaluate dry powder inhalers of Budesonide for pulmonary delivery. Dry powder inhalers of Budesonide were prepared using different concentrations of fine lactose and magnesium stearate by Geometric dilution method. The drug-carrrier compatibility study was carried out by FT-IR studies. A total of eleven batches were formulated and evaluated for physical appearance, average fill weight, flow properties, particle size analysis, content uniformity, moisture content and assay. In-vitro drug deposition studies were carried out by using Modified Twin Stage Impinger (TSI) apparatus. Of all eleven batches, the formulation F4, comprising of fine lactose 30% was found to be the best having comparatively higher fine particle fraction (FPF) of 25.32%. The result indicated that the amount of drug that reaches in the lung was higher for formulation F4. Further invivo safety and deposition studies on suitable animal models and human volunteers will give better insight for clinical applications of the Budesonide DPI.

Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Thiruvananthapuram is an Institute of National Importance  established by an Act  of the Indian Parliament  and  under the 2 administrative control of the Department of Science and Technology, Government of India.