BHU

Banaras Hindu University ranks among the first few in the country in the field of academic and research output. This university has two campuses, 3 institutes, 16 faculties, 140 departments, 4 advanced centers and 4 interdisciplinary schools.

Banaras Hindu University ranks among the first few in the country in the field of academic and research output.

Banaras Hindu University ranks among the first few in the country in the field of academic and research output.

Banaras Hindu University ranks among the first few in the country in the field of academic and research output.

Banaras Hindu University ranks among the first few in the country in the field of academic and research output.

Banaras Hindu University ranks among the first few in the country in the field of academic and research output.

Banaras Hindu University ranks among the first few in the country in the field of academic and research output. This university has two campuses, 3 institutes, 16 faculties, 140 departments, 4 advanced centers and 4 interdisciplinary schools.

About Author: Rinki Verma (Research fellow)
Center of Experimental Medicine and Surgery,
Institute of Medical science
Banaras Hindu University
Varanasi - 221005

Abstract:
In 1965 ,  firstly fragility was reported in cells of  a femeal previously irradiated and described  as non-random human chromosome called “ Fragile sites”  are heritable specific chromosome loci that exhibit an increased frequency of gaps, poor staining, constrictions or breaks when chromosomes are exposed to partial DNA replication inhibition. They constitute areas of chromatin that fail to compact during mitosis. They are classified as rare or common depending on their frequency within the population and are further subdivided on the basis of their specific induction chemistry into different groups differentiated as folate sensitive or non-folate sensitive rare fragile sites, and as aphidicolin, bromodeoxyuridine (BrdU) or 5-azacytidine inducible common fragile sites. Most of the known inducers of fragility share in common their potentiality to inhibit the elongation of DNA replication, particularly at fragile site loci. There are seven non-similar folate sensitive (FRA10A, FRA11B, FRA12A, FRA16A, FRAXA, FRAXE and FRAXF) and two non-folate sensitive (FRA10B and FRA16B) and  have been molecularly characterized. Due to dynamic mutation formed DNA repeat sequences and  involving the normally occurring polymorphic CCG/CGG trinucleotide repeats at the folate sensitive and AT-rich minisatellite repeats at the non-folate sensitive fragile sites. These rare fragile site FRAXA is the most important fragile site as it is associated with the fragile X syndrome significant to the clinical side and also explained the predisposition of tumors.

About Author: Rinki Verma (Research fellow)
Institute of Medical science (CEMS)
Banaras Hindu University
Varanasi - 221005

Abstract:
Gallbladder cancer is a comparatively rare cancer and has poor outcome due to their anatomy and location. It has peculiar geographical distribution being common in central and South America, central and eastern Europe, Japan and northern India; it is also common in certain ethnic groups e.g. Native American Indians and Hispanics (Kapoor VK, McMichael AJ ,2003. It is fifteen uncommon cancers in the world with high mortality rate. The diagnosis is made very late due to its silent course. The majority of patients have advanced disease at the time of presentation which carries a poor prognosis. The modes of spread of gall bladder carcinoma are direct, lymphatic, vascular, neural, intraperitoneal and intraductal. Ultra Sound, CT and MRI are helpful in diagnosis and staging of the disease. Surgery remains the mainstay of treatment and chemotherapy has a very limited role.