About Authors:
Singh khushboo, Sharma monica,
Ram gopal college of pharmacy,
Gurgaon
ABSTRACT
Approximately 40% of new drug candidate have poor water solubility and oral delivery of such drug is frequently associated with implications of low bioavailabilty,high inter and intra subject variability, lack of dose proportionality. Bioavalibilty of lipophilic drug can be solved by formation of self emulsifying drug delivery system.SEDDS are belongs to lipid formulation and size range is from 100nm[SEDDS] less than 50nm[SMEDDS] and contain a isotropic mixture of oil, surfactant and co surfactant which are emulsified in aqueous media under condition of gentle agitation. The theory behind dissolution rate improvement by means of SEDDS is the spontaneous development of emulsion in GIT with mild agitation provide by gastric motility, which present the drug in solubilized form,small size of formed droplet provided a large inter facial area for absorption,due to small globule size thAT can be easily absorb through lymphatic pathway, thereby passing hepatic pathway.