Tamil Nadu

The Vinayaka Mission’s College of Pharmacy (VMCP), Salem, established in the year 1982 is the pioneer institution of the Thirumuruga Kirupananda Variyar Thavathiru Sundara Swamigal (TKVTSS) Medical Educational and Charitable Trust. It plays a vital role in the field of Pharmacy education and caters to the needs of society by meeting the ever-increasing demand for pharmacists in India and abroad. The college that started with the Diploma in Pharmacy program now also offers B.Pharm (from 1993), M.Pharm (from 2003) in 5 specializations, Pharm.D, Pharm.D (Post Baccalaureate) (from 2009) and the Doctoral Program in Pharmacy (from 2004). The college is a constituent college of Vinayaka Missions University, Salem and is approved by the Pharmacy Council of India, New Delhi. Several hundreds of students have graduated from the college successfully and are practicing the profession of Pharmacy across the globe and serving the community at large.

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Post: Associate Research Analyst/ Research Analyst

The Christian Medical College believes that research plays an integral role in developing health care professionals with a commitment to excellence...

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ABOUT AUTHORS
Subashini Rajaram, Abirami Murugan, Nidhina Raj C.M
Swamy Vivekanandha College of Pharmacy, Namakkal, Tamilnadu, India.
Life Pharmacy, Al Barsha, Dubai-UAE
subababu.r@gmail.com

ABSTRACT
Degradation of rifampicin (RIF) to insoluble and poorly absorbed 3-Formyl rifamycin SV (3-FRSV) in acidic environment is a major concern which leads to reduction in the bioavailability of RIF and is further influenced by the presence of isoniazid (INH) in the stomach after ingestion. It is recommended that addition of ascorbic acid (ASC) in dissolution medium, in plasma as antioxidant to stabilize RIF from degradation and also daily intake of ASC to control tuberculosis (TB).Though the effect of ASC on fixed dose combination (FDC) products has not been traversed and hence examined in the present study.  The rate of degradation of RIF to 3-FRSV in the presence of ASC in dissolution medium (0.1 N HCl) on market formulations was estimated by Dual Wavelength UV–Vis. spectrophotometry (DW spectrophotometry) and High performance liquid chromatography (HPLC) method. Addition of ASC in FDC formulations lowered significantly formation of 3-FRSV or degradation of RIF as compared to that without ASC in in-vitro. Our study proposed that co-package of ASC with fixed dose combination products (FDC) can protect RIF degradation in the acidic environment and in-vivo investigation needed to predict the bioavailability of RIF in FDC products in the presence and absence of ASC for effective control of TB.

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Inspired and moved to share  below the essence of a true story which has unfolded in our own country in the recent past and in our own midst:

ICON is a global provider of outsourced development services to the pharmaceutical, biotechnology and medical device industries. We specialize in the strategic development, management and analysis of programs that support Clinical Development – from compound selection to Phase I - IV clinical studies ICON enjoys a strong reputation for quality and is focused on staff development. We make it our mission to attract the most diverse and creative minds into the business and we continually strive to provide opportunities for our people to excel, grow and build a great career. We understand that our greatest asset is the skills and talents of our people and they are truly what set us apart.

Post: Manager Drug Safety