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  • SOLID DISPERSION: A TOOL TO ENHANCE SOLUBILITY OF POORLY WATER SOLUBLE DRUGS

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Ravindra M Hanwate*1, Dehghan M H G2, Saifee M2
    1Department of Pharmaceutics, Dr.Vedprakash Patil College Of Pharmacy, Auranganad, Maharashtra, India
    2Department of Pharmaceutics, Y.B.Chavan College of Pharmacy, Aurangabad, Maharashtra, India
    * ravi_hanwate@yahoo.co.in

    ABSTRACT
    Solid dispersions have been used to increase the dissolution rates of poorly water soluble drugs. Many methods are used to prepare solid dispersions. This paper reports various solubility enhancement strategies in solid dispersion. The methods described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, spray drying technology, use of surfactant. The paper also shows study of characterization, selection of carriers, potential applications and limitations of these methods in solid dispersion.

  • Career for Sr Manager SCM (Demand and Supply Planing ) @ Major generic and API manufacturer- ABC Consultant

    one of the world’s leading generics and specialty pharmaceutical companies, providing products to customers in approximately 140 countries and territories. The company maintains one of the industry’s broadest and highest quality product portfolios, which is regularly bolstered by an innovative and robust product pipeline. With a workforce of more than 20,000, has attained leading positions in key international markets through its wide array of dosage forms and delivery systems, significant manufacturing capacity, global commercial scale and a committed focus on quality and customer service.
    one of the world’s largest active pharmaceutical ingredient (API) manufacturers. one of only two global generics companies with a comprehensive, vertically integrated supply chain. also is one of the world’s largest producers of API used to make generic antiretroviral (ARV) therapies for the treatment of HIV/AIDS.

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  • TOXICOLOGICAL ASPECTS OF ARIPIPRAZOLE- A NEW ANTIPSYCHOTIC DRUG: REVIEW ARTICLE

    About Author:
    Renuka G. Hade
    Quality Assurance Department, Wockhardt Limited,
    Aurangabad (431210), M.S.
    renukahade@gmail.com

    Abstract:
    Aripiprazole is a new antipsychotic agent. There is presently no evidence to suggest that it is more effective than existing antipsychotics in the treatment of schizophrenia but it offers prescribers another treatment option for this illness. Its efficacy in treatment-resistant schizophrenia is not established; for these patients clozapine is generally considered the drug of choice.
    Aripiprazole is a widely used antipsychotic drug supplied in various dosage forms of Aripiprazole Tablets, Aripiprazole Orodispersible tablets and Aripiprazole Oral solution. These formulations are approved by United States Food and Drug Administartion (USFDA) and European Medicinal Agency (EMA) under the brand name Abilify®, manufactured by Otsuka Pharmaceuticals Limited.1
    Based upon the current market demands of the Aripiprazole worldwide, a complete review of the non-clinical (Animal) safety (toxicological studies), is of considerable importance.

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  • Opening for R&D Team Member in Mylan

    Mylan is one of the world’s leading generics and specialty pharmaceutical companies, providing products to customers in more than 150 countries and territories. The company maintains one of the industry’s broadest and highest quality product portfolios, which is regularly bolstered by an innovative and robust product pipeline.

  • WALK IN INTERVIEW | Work as Sales Officers in Shreya Lifesciences

    Shreya Group has interests in both pharmaceutical and biopharmaceutical products in key therapeutic segments. Currently, Shreya operates in Russia, CIS, India, South East Asia and African countries. The Group turnover for the year 2006 was US $ 581 million including US $ 85 million in India.

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