Modern analytical techniques - Solved Paper 2006-07

M.Pharma

First semester examination, 2006-2007-

Modern analytical techniques

Dr A.P.J. Abdul Kalam Technical University

Q1. Attempt any Two of the following:

(a) Draw an optical diagram of spectrofluorometer. Give its theory and pharmaceutical applications.

(b) Discuss theory and pharmaceutical applications of X-Ray diffraction spectroscopy.

(c) Explain origin of uv/visible absorption spectrum through it. What information may be sought regarding structure of organic compounds?

Q2. Attempt any Two of the following:

(a) Write an exhaustive note on thermogravimetry.

(b) Explain frequency shift due to inductive and mesomeric effects in IR spectroscopy.

(c) How will you distinguish:
(i) 10⁰,20⁰, and 30⁰ aliphatic amines.
(ii) 10⁰,20⁰, and 30⁰ aliphatic alcohols and phenols.
(iii) Alkane, alkene, alkyne and arene from each other.

Q3. Attempt any Two of the following:

(a) How will you differentiate betweenfirst order and non-first order PMR spectra?

(b) How will you simplify complicated splitting pattern in PMR? Differentiate between PMR and 13 CNMR.

(c) Discuss principle and quantitative and qualitative applications of ESR.

Q4. Attempt any Two of the following:

(a) Give difference stationary phases used in different modes of HPLC.

(b) Discuss about carrier gases, column and solid support stationary phases in GLC.

(c) Elaborate factors affecting electrophoretic mobility.

Q5. Attempt the following:

(a) Draw diagram of apparatus and give methodology of DTA. Discuss factors affecting DTA results.

(b) How will you ascertain purity of sample by DSC? Discuss its principle.

ABOUT AUHTORS
Mr. Dharmendra Kumar M.Pharm. (Pharmaceutics), Ms. Sakshi Gupta M.Pharm. (Pharmaceutical Chemistry)
Phd(p) Assistant Professor, Dr A.P.J. Abdul Kalam Technical University, Lucknow

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