NOV 2014 ARTICLE LIST >>
PharmaTutor (November- 2014)
ISSN: 2347 - 7881
(Volume 2, Issue 11)
Received On: 26/09/2014; Accepted On: 30/09/2014; Published On: 01/11/2014
AUTHORS: R.Meera1*, N.Swathylakshmi2, M.Sundarapandian2, P.Raja Soundara Pandian1, Madhavanmallayasamy1
1Researcher, Radianz Health Care Pvt Ltd, Madurai, Tamilnadu, India
2Department of pharmaceutical chemistry, K.M.College of pharmacy, Uthangudi, Madurai, India
meeraharsa23@gmail.com
ABSTRACT:
Objectives:
A simple spectrophotometric method was developed and validated for the determination of Nitaoxanide in pharmaceutical dosage forms. Two visible spectrophotometric methods have been described for the assay of Nitaoxanide bulk form or dosage forms.
Methods: Method A is based on the formation of Schiff’s base and it was condensed with 4 hydroxybenzaldehyde. Method B is based on diazotization and coupling method with phluroglucinol. The methods are done in UV Visible spectrophotometric method having maximum absorbance at 460 nm.
Results: Regression analysis of Beers law plots showed good concentration range of 10-50µg/ml for method A and B and gives reproducible results.
Conclusion: Due to its simplicity of the method it may be used for determining Nitaoxanide in bulk and dosage forms.
How to cite this article: R Meera, N Swathylakshmi, MS Pandian, PRS Pandian, M Mallayasamy; Spectrophotometric Methods for the Determination of Nitaoxanide in Bulk Drug and its Pharmaceutical Formulation; PharmaTutor; 2014; 2(11); 120-127
[ABSTRACT WITH CITATION] [VIEW AS HTML]
REFERENCES:
1. drugbank.ca/drugs/ DB00507.
2. Prabhakar G, Kapse, Appala G.K; Spectrophotometric determination of Nitazoxanide in pharmaceutical dosage form; Indian Journal of Pharmaceutical Sciences; 2006; 3(68); 403- 406.
3. Singh H.P., Sharma C.S., Amar Deep Angali, Agalann S.K., Ranawat M.S;Spectrophotometric methods for simultaneous determination of Nitazoxanide and Ofloxacin in combined bulk and pharmaceutical formulations. International Journal of Pharm Tech Research; 2011;3:118-123.
4. Vanitha J, Kumar A, Saravana, Ganesh M, Vetrichelvan T; Estimation of Nitazoxanide by UV Spectrophotometric method; Journal of Global Pharma Technology; 2009; (1): 51-53.
5. Senthilraja, Simultaneous UV Spectrophotometric method for the estimation of nitazoxanide and ofloxacin in combined dosage form; Research J.Pharm and Tech; 2008;1(4):469-471.
6. ShailendraBindaiya, ShravanBankey, Deepi Jain; Simultaneous determination of Nitaoxanide and ofloxacin in tablet by ultraviolet Spectrophotometry (dual wavelength method). International Journal of ChemTech Research; 2; 2010:11-15.
7. Lakshminarayana K.V., Manohara Y.N., Gurupadayya B.M., Development and validation of spectrophotometric methods for the estimation of nitazoxanide in tablet dosage forms; Indian Journal of Pharmaceutical Sciences; 2007;69(1):147-149.
8. Sharma M.S., Sharma M.C; Development of visible spectrophotometric methods for the estimation of Nitaoxanide in bulk and pharmaceutical formulation using ferric chloride., American-Eurasian Journal of Scientific Research;2011; 6(3):155-160.
9. VidyaSagar, Syed AzharNizami, Gurumurthy, Ramesh MR; Colorimetric Estimation of Nitazoxanide and Ofloxacin in Pharmaceutical Dosage from., International Journal of Pharma Research and Development; 3:199-206.
10. Lopamudra Adhikar, Sanjiv Sahu, Sarbeswar Jagdev; Development and validation of spectrophoto metric and colorimetric method for the determination of Nitazoxanide in its bulk and pharmaceutical dosage form (Tablet);International Journal of Chem Tech Research; 2011; 3(1): 131-135.
11. Marcelo Donald Malesuik, ClesioSoldatelli Paim, Elfrides Eva Scherman Schapovale, Martin Steppe; Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with HPLC;Quim.nova.2010; 33:3
12. Sharma M.C., Sharma M.C; Development and validation of a dissolution method with isocratic high performance liquid chromatographic determination of Nitaoxanide and ofloxacin in pharmaceutical dosage form; American- Eurasian Journal of Scientific Research; 2011, 6(3):155-160.
13. Hanna S. El-Desoky, Mohamed M. Ghoneim and Mohamed M. Abdel-Galeil; Stripping Volumetric methods for determination of the Ant parasitic drug Nitaoxanide in bulk form, pharmaceutical formulation and human serum; J. Braz. Chem Soc; 2010; 21(4):669- 679.
14. Gopu C.L., Shibu Thomas, Paradkar A.R., Mahadik K.R; A validated stability indicating HPTLC method for the determination of nitazoxanide; Journal of scientific and industrial Research; 2007; 66:141-145.
15. Siva Kumar R, Kumar Nallasivan P, Saravanakumar S, Kandasamy and Venkatnarayanan R; Simultaneous RP-HPLC estimation of Nitazoxanide and ofloxacin in tablet dosage forms., Asian Journal of Research Chem; 2009; 2(1):43-45.
16. Premanand D.C., Senthilkumar K.L., Senthilkumar B., Saravanakumar M., Thirumurthy R; A validated RP-HPLC method for simultaneous estimation of nitazoxanide and ofloxacin in pharmaceutical formulations; Pelagia Research Library; 2010;1(2):1-5.
17. Sharna S, Bhandari A, Choudhari VR, Rajpurohit H; RP-HPLC method for Simultaneous estimation of nitazoxanide and ofloxacin in tablets; Indian Journal of Pharmaceutical Sciences; 2011: 84-88.
18. Katla R, Sharma R, Chaturvedi S; Simultaneous RPHPLC determination of nitazoxanide and ofloxacin in combined tablet dosage form (Reverse phase high performance liquid chromatography) (clinical report); Indian Journal of Pharmaceutical Sciences; 2008; 1:38.
19. Beckett A.H., Stenlake J.B., Practical pharmaceutical chemistry; Jain SK for CBS Publishers and distributors; Part 1, 1997, 1-17.
20. Linda L.N., Review Guidance-Validation of chromatographic methods, Centre for drug evaluation and research; 1994, 1-30.
21. ICH-Q2B, Validation of analytical procedure. Methodology, ICH. Harmonized Tripartite Guideline, Geneva, 1996, 1-8.
22. ICH-Q2A, Text on validation of analytical procedures, ICH. Harmonized Tripartite Guideline, Geneva, 1995, 2-3, A-1 to A-3.
.png)
