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PharmaTutor (May- 2014)
ISSN: 2347 - 7881
Received On: 03/03/2014; Accepted On: 11/03/2014; Published On: 01/05/2014
Author: Nandu Kayande1*, Pankaj Kushwah2, D.K. Vir3
1HOD Department of Pharmacology
2Department of Pharmacognosy
3Department of Pharmacology
Nimar Institute of Pharmacy, Dhamnod,
Dhar, Madhya Pradesh, India
*nandu_kayande@rediffmail.com
ABSTRACT:
The objective of present study was to evaluate in vivo anti-diarrheal potential of Cinnamon leaves. Sample was analyzed for quantities estimation of photochemical and anti-diarrheal activity of aqueous leaf extract, at 100, and 200 mg/kg body weight (b.w) was investigated using castor oil induced model. The aqueous leaves extract of Cinnamon leaves (100, and 200 mg/kg body weight) was administered orally to three groups of rats (five animals per group) in order to evaluate the activity of the extract against castor oil-induced diarrhea model in rat. Two other groups received normal saline (5mg/kg) and Loperamide (2mg/kg) as positive control. The effect of the extract on castor oil-induced diarrhea, gastrointestinal transit and intestinal fluid accumulation (enter pooling) was assessed respectively. In this study, the phytochemical analysis of aqueous leaves extract of Cinnamon leaves revealed the presence of alkaloids, terpenoids, flavonoids, saponins, tannins and phenols. At oral doses of 100, and 200 mg/kg body weight, the plant extract showed pronounced significant (p<0.05) antidiarrhoeal activity compared to the control group. No mortality and visible signs of general weakness were observed in the rats following the extract administration of up to a dose of 2000 mg/kg. The results showed that the aqueous leaves extract of Cinnamonleaves has a significant antidiarrhoeal activity which supports its use in traditional herbal medicine practice.
How to cite this article: N Kayande, P Kushwah, DK Vir; Evaluation of Anti Diarrheal Potential of Cinnamon Leaves; PharmaTutor; 2014; 2(5); 124-127
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