JULY 2015 ARTICLE LIST >>
PharmaTutor (July- 2015)
Print-ISSN: 2394 - 6679
e-ISSN: 2347 - 7881
(Volume 3, Issue 7)
Received On: 17/03/2015; Accepted On: 30/03/2015; Published On: 01/07/2015
AUTHORS: Shashi Shekhar Anand, Navgeet, Balraj Singh Gill*
Centre for Biosciences, School of Basic and Applied Sciences,
Central University of Punjab, Bathinda, India
*gillsinghbalraj@gmail.com
ABSTRACT: The word ‘epigenetic’ was first coined by Conrad Waddington in 1946. It deals with functionally relevant modifications to the genome that do not include a change in the nucleotide sequence. Till date observation has focused on the functions of genome sequences and how their regulation occurs. The emerging epigenetic changes and the interactions between cis-acting elements with protein factors plays a central role in gene regulation as well as give insight to various diseases. To evaluate the crosstalk of DNA and protein by taking account of the whole genome, one new evolving technique which is called as ChIP-chip, works on the principle of combining chromatin immunoprecipitation with microarray. ChIP-chip has been recently used in basic biological studies and may be improved further and can be useful for other to aspects, like human diseases. Now a days large amount of discoveries by ChIP-chip and other high-throughput techniques like this may be connected with evolving bioinformatics to add to our knowledge of life and diseases.
How to cite this article: SS Anand, Navgeet, BS Gill; Breakthroughs in Epigenetics; PharmaTutor; 2015; 3(7); 16-24
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REFERENCES:
1. Rakyan VK and Stephan Beck., Epigenetic variation and inheritance in mammals, Current Opinion in Genetics & Development, 2006; 16; 573-577.
2. Jaenisch R. & Bird A; Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nature genetics, 2003; 33; 245-254.
3. Kütting B., Bonsmann G., Metze D., Luger T.A. & Cerroni L; Borrelia burgdorferi associated primary cutaneous B cell lymphoma: complete clearing of skin lesions after antibiotic pulse therapy or intralesional injection of interferon alfa-2a; Journal of the American Academy of Dermatology; 1997; 36(2): 311-314.
4. Richmond T.J. & Davey C.A; The structure of DNA in the nucleosome core; Nature; 2003; 423(6936); 145-150.
5. Bird A; Perceptions of epigenetics; Nature; 2007; 447(7143); 396-398.
6. Jones P.A. & Baylin S.B; The fundamental role of epigenetic events in cancer. Nature Reviews Genetics; 2002; 3(6); 415-428.
7. Robertson K.D; DNA methylation, methyltransferases, and cancer; Oncogene; 2001; 20(24); 3139-3155.
8. Champion, C., Guianvarc'h, D., Sénamaud-Beaufort C., Jurkowska, R. Z., Jeltsch A., Ponger L.; Guieysse-Peugeot, A.-L. Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine; PloS one, 2010; 5(8); e12388.
9. Luczak M.W., Roszak A, Pawlik P, Kedzia H, Kedzia W, Malkowska-Walczak, Jagodzinski P.P; Transcriptional analysis of CXCR4, DNMT3A, DNMT3B and DNMT1 gene expression in primary advanced uterine cervical carcinoma; International journal of oncology; 2012; 40(3); 860-866.
10. Soto-Reyes E., González-Barrios R., Cisneros-Soberanis F., Herrera-Goepfert R., Pérez V, Cantú D, Herrera, LA; Disruption of CTCF at the miR-125b1 locus in gynecological cancers; BMC cancer; 2012; 12(1); 40.
11. Turek-Plewa J, & Jagodzinski P. The role of mammalian DNA methyltransferases in the regulation of gene expression; Cellular and Molecular Biology Letters; 2005; 10(4); 631.
12. Kanwal R. and Gupta S; Epigenetics and cancer; Journal of Applied Physiology; 2010; 109(2): 598-605.
13. Krebs J., Lewin B, Goldstein ES, & Kilpatrick ST; Lewin's essential genes; Jones & Bartlett Publishers; 2013.
14. Tollefsbol T; Handbook of epigenetics: the new molecular and medical genetics; Academic Press, 2010.
15. Mann Derek A; Epigenetics in liver disease; Hepatology; 2014; 60(4); 1418-1425.
16. Völkel P., Angrand P.-O; The control of histone lysine methylation in epigenetic regulation; Biochimie; 2007; 89(1); 1-20.
17. Nelissen EC, van Montfoort AP., Dumoulin JC, Evers, JL; Epigenetics and the placenta; Human reproduction update; 2011; 17(3); 397-417.
18. Kouzarides T; Chromatin modifications and their function; Cell; 2007; 128(4); 693-705.
19. Bollati V, Baccarelli A. Environmental epigenetics; Heredity; 2010; 105(1); 105.
20. Shen J, Wang S, Zhang YJ, Kappil M, Wu HC, Kibriya MG, Lee PH; Genome-wide DNA methylation profiles in hepatocellular carcinoma; Hepatology; 2012; 55(6); 1799-1808.
21. Carone BR, Fauquier L, Habib N, Shea JM, Hart CE, Li R, Zamore PD; Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals; Cell; 2010; 143(7); 1084-1096.
22. Murphy SK, Yang H, Moylan CA, Pang H, Dellinger A, Abdelmalek MF, Tillmann HL; Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease; Gastroenterology; 2013; 145(5); 1076-1087.
23. Wu J, Smith LT, Plass C, Huang TH; ChIP-chip comes of age for genome-wide functional analysis; Cancer research; 2006; 66(14); 6899-6902.
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