A Potent Target for Cancer Treatment – Tumor Hypoxia Necrosis: An Overview

JUL 2014 ARTICLE LIST >>

PharmaTutor (July- 2014)
ISSN: 2347 - 7881

Received On: 27/04/2014; Accepted On: 09/05/2014; Published On: 01/07/2014

AUTHORS: Pankaj Dinkar Patil*, Raju Tayade
Department of Pharmaceutical sciences and technology,
ICT Mumbai, Maharashtra, India
pankaj.patil46@gmail.com

ABSTRACT:
Tumor hypoxia is feature of locally advancing solid tumor and also considered as potential therapeutic challenge. It causes solid tumor resistible to the cancer treatment like radiation and chemotherapeutic drugs. The transcription factor HIF-1 is the major player in the regulation of tumor progression into malignant phenotype. We can target this hypoxic conditions using pathophysiological approach for targeted drug delivery for treatment of cancer. This review will focus on various biological aspects of tumor hypoxia necrosis and approaches for targeting hypoxic tumors. This tumor selective treatment will include bioreductive drugs, gene therapy, and recombinant bacteria.

How to cite this article: PD Patil, R Tayade; A Potent Target for Cancer Treatment – Tumor Hypoxia Necrosis: An Overview; PharmaTutor; 2014; 2(7); 8-28

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