January 2017 ARTICLE LIST >>
PharmaTutor (January - 2017)
ISSN: 2347 - 7881
(Volume 5, Issue 1)
Received On: 25/08/2016; Accepted On: 17/09/2016; Published On: 01/01/2017
AUTHORS:
Akash S Mali1,2*,Audrius Maruška2
1 Institute of Virology and Immunbiology ,
University of Würzburg Germany.
2 Vytautas Magnus University, Lithuania
*Akashmit97@gmail.com
ABSTRACT: Pharmaceutical gases molecules (Therapeutic medical Gases) are plays vital role in various disease conditions. In particular, Carbon monoxide, Oxygen, Nitric oxide, Hydrogen sulfide are generated in the human body and mediate signaling pathways as biological messengers and shown pharmacological effects on cardiovascular disorders, nervous system, respiratory track and gastrointestinal disorder. Appropriate oral delivery of gases is challenging concept in front of novel drug delivery system, recently microbubbles, nanobubbles, liposomes, ultrasound technology provides new oral and parenteral delivery platform for therapeutic gases. This review provides pharmacological effects of therapeutic medical gases and its novel delivery aspects.
How to cite this article: Mali AS, Maruška A;Therapeutic Gases Pharmacology and It’s Advanced Delivery; PharmaTutor; 2017; 5(1); 37-41
[ABSTRACT WITH CITATION] [VIEW AS HTML]
REFERENCES:
1. Buchholz BM et al. "Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury." American Journal of Transplantation 8.10 (2008): 2015-2024.
2. Mocellin, Simone, Vincenzo Bronte, and Donato Nitti. "Nitric oxide, a double edged sword in cancer biology: searching for therapeutic opportunities."Medicinal research reviews 27.3 (2007): 317-352.
3.Ikeda, Hideaki, et al. "Fatal and nonfatal poisoning by hydrogen sulfide at an industrial waste site." Journal of Forensic Science 47.3 (2002): 652-655.
4. Liu, Wenwu, et al. "Is methane a new therapeutic gas?." Medical gas research 2.1 (2012): 1.
5. Fix, Samantha M., Mark A. Borden, and Paul A. Dayton. "Therapeutic gas delivery via microbubbles and liposomes." Journal of Controlled Release 209 (2015): 139-149.
6. Steiger, Christoph, Tessa Lühmann, and Lorenz Meinel. "Oral drug delivery of therapeutic gases—Carbon monoxide release for gastrointestinal diseases." Journal of Controlled Release 189 (2014): 46-53.
7.Huang, Shao-Ling, and Robert C. MacDonald. "Acoustically active liposomes for drug encapsulation and ultrasound-triggered release." Biochimica et Biophysica Acta (BBA)-Biomembranes 1665.1 (2004): 134-141.
8. Tao, Zhimin, and P. Peter Ghoroghchian. "Microparticle, nanoparticle, and stem cell-based oxygen carriers as advanced blood substitutes." Trends in biotechnology 32.9 (2014): 466-473.
9. Rudic, Radu Daniel, et al. "Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling." Journal of Clinical Investigation 101.4 (1998): 731.
10. Ma, D., et al. "Neuroprotective and neurotoxic properties of the ‘inert’gas, xenon." British Journal of Anaesthesia 89.5 (2002): 739-746.
11. Britton, George L., et al. "In vivo therapeutic gas delivery for neuroprotection with echogenic liposomes." Circulation 122.16 (2010): 1578-1587.
12. Roccarina, Davide, et al. "The role of methane in intestinal diseases." The American journal of gastroenterology 105.6 (2010): 1250-1256.