August 2016 ARTICLE LIST >>
PharmaTutor (August - 2016)
Print-ISSN: 2394 - 6679
e-ISSN: 2347 - 7881
(Volume 4, Issue 8)
Received On: 18/02/2016; Accepted On: 13/03/2016; Published On: 01/08/2016
AUTHORS:
C.V.H.Hemavathy*, B. Raj kumar, R. Kiran kumar, G. Hema latha
Faculty of Pharmacy,
Kottam Institute of Pharmacy, Erravally X Roads, Mahaboob Nagar, India
*hemarayudu19@gmail.com
ABSTRACT: To evaluate the mechanism of hepatoprotection in terms of Liver antioxidant mechanism, histopathological study, the animals were divided into Four groups of three animals each. Except the normal group all the other groups received CCl4 in at a dose of 0.1 ml/kg by intraperitoneally for 14 days. Normal groups received plain tween 80 orally. On the 14th day all the rats from all the groups were sacrificed, blood was collected from each animal for serum analysis and their livers were stored under freezing conditions for the estimation of endogenous anti oxidants and one sample from each group was stored in 10% formalin for histopathological studies. In bio-chemical studies- Serum analytical methods (AST), (ALT), (Alk.P), (Bil), (TP), (TC). The present findings observed in this study revealed that, glimepiride is natural antioxidant lignin possess significant antioxidant activity against CCl4 induced hepatotoxicity via antioxidant mechanism. However, further research is required to find out the other possible mechanism of hepatoprotection to conform that as glimepiride hepatoprotective molecule.
How to cite this article: Hemavathy CVH, Kumar BR, Kumar RK, latha GH; Hepatoprotective activity of glimepiride by inducing CCl4 hepatotoxicity; PharmaTutor; 2016; 4(8); 42-48
[ABSTRACT WITH CITATION] [VIEW AS HTML]
REFERENCES:
1. Hukkeri. VL, KusomsAkki. M, Sureban. RR, Gopala Krishna. B, Byahatti. VV andRajendra. S.V; Hepatoprotective activity of the leaves of Nyctanthes arbortristis Linn; IJPS; 2006; 68(4); 542-543.
2. Zimmerman HJ; Drug-induced liver disease; The Adverse Effects of Drugs and Other Chemicals on the Liver. 2nd ed. Philadelphia, PA: Lippincott Williams &Wilkins; 1999; 427-456.
3. Lasser KE, Allen PD, Woolhandler SJ, Himmelstein DU, Wolfe SM, Bor DH; Timing of new black box warning and withdrawals for prescription medications; JAMA; 2002; 287(17); 2215-2220.
4. Temple RJ, Himmel MH; Safety of newly approved drugs: implications for prescribing; JAMA; 2002; 287(17); 2273-2275.
5. Michael P. Holt and Cynthia Ju; Mechanisms of Drug Induced Liver Injury; AAPS Journal; 2006; 8(1); 48-54.
6. Gerard J. Tortora, Sundra Reynolds Grabowski; Priniciple of anatomy and physilogy; 7th Ed.; 1993; 790-795.
7. Kamal E. H. El-Tahir, Othman A, Gubara and AbdulaRahma M. Ageel ; Conventional drugs and herbal medicines induced hepatotoxilcity; Saudi Pharmaceutical Journal;2005; 13(4); 129-138.
8. Sherwood and Lauralee; Human physiology: from cells to systems; 3rd ed. Boston:Wadsworth; 1997; 790-795.
9. Tzanakakis; Liver assist Devices; Annual review of Biomedical Engineering 2; 607-632. (2000) 542-543.
10. Jafri. M.A, JalisSubhani. M, Kalim Javed, Surender Singh; Hepatoprotective activity of leaves of Cassia occidentalis against paracetamol and ethyl alcohol intoxication in rats; Journal of Ethnopharmacology; 1999; 66(3); 355–361.
11. Kumar. G, Sharmila Banu. G, Vanitha Pappa. P, Sundararajan. M, Rajasekara Pandian. M; Hepatoprotective activity of Trianthema portulacastrum L. against paracetmol and thioacetamide intoxication in albino rats; Journal of Ethanopharmacology; 2004; 92(1); 37-40.
12. Shanumuga sundaram and Venkataraman; Hepatoprotective and antioxidant effects of Hygrophila auriculata (K. Schum) Heine Acanthaceae root extract; Journal of Ethnopharmacology; 2006; 104(1-2); 124–128.
13. Yong Woo Choi, Seung Oh Rew, OuKyoung Kwon and Se Ung Chon; Changes of SGOT and SGPT after halothane, Enflurane and Thalamonal Anesthesia; The Journal of Korean Society of Anesthesiologists; 1984; 17(1); 12-16.
14. Elise Andrews, Ann K. Daly; Flucloxacillin induced liver injury; Toxicology; 2008; 254(3); 158-163.
15. Friedman, Scott E, Grendell, James H, Mc Quaid, Kenneth R; Current diagnosis and treatment in gastroenterology; N New Yark. Lang Medical Books, McGrwHill; 2003; 664-679,
16. Ganesh Rajaraman, Jie Chen, Thomas K.H. Chang (2006) Ginkgolide; 1997; 790-795.
17. Nilesh Mehta, Lisa Oxick, Emmanuel Gbadeham (2008) ; Drug induced hepatotoxicity; emedicine. 1993; 790-795.
18. Kamal E. H. El-Tahir, Othman A, Gubara and AbdulaRahma M. Ageel; Conventional drugs and herbal medicines induced hepatotoxilcity; Saudi Pharmaceutical Journal; 2005; 13(4); 129-38.
19. Jussi J. Saukkonen, David L. Cohn, Robert M. Jasmer, Steven Schenker, John A. Jereb, Charles M. Nolan,Charles A. Peloquin, Fred M. Gordin, David Nunes, Dorothy B. Strader, John Bernardo, Raman Venkataramanan, and Timothy R. Sterling; An official ATS statement: Hepatotoxicity of antituberculosis therapy; Am JRespir. Crit. Care. Med.; 2006; 174(8); 935–952.
.png)
