April 2018 ARTICLE LIST >>
PharmaTutor (April - 2018)
ISSN: 2347 - 7881
(Volume 6, Issue 4)
Received On: 18/01/2018; Accepted On: 12/02/2018; Published On: 01/04/2018
AUTHORS:
Sabir Shaikh*1, Amol Shete2, Rajendra Doijad3
1S. Kant Health care R&D Centre
Turbhe, Navi Mumbai, Maharashtra, India
2Department of pharmaceutics,
Krishna institute of Pharmacy of Krishna institute medical sciences Deemed university,
Karad, Maharashtra, India.
3 Department of Pharmaceutics and Quality Assurance,
Shree Santkrupa College of Pharmacy Ghogaon, Karad, Maharashtra, India.
*sabirmshaikh17@gmail.com
ABSTRACT:
The objectives of present investigation were to formulate and evaluate herbal gel for mouth ulcer treatment of dried powdered guava leaves.
Herbal gel was prepared by using different concentration of powdered guava leaves and Carbopol 934, Propylene glycol as a gel base. Formulations were evaluated for various parameters
Infrared spectroscopy revealed that there was no interaction between powdered Guava leaves and Polymer. The formulated gel was transparent, homogeneous and pH ranges from 7 to 7.5. Formulation showed acceptable rheological behaviour with applicable Spreadability and Extrudability properties. Anti-fungal studies of formulations showed excellent efficacy against Aspargilious aureus, Candida albicans.
From the experimental evidence of invitro studies it was observed that powdered guava leaves contain flavonoids so it showed significant antioxidant effect.
Developed herbal formulation was stable, safe and effective over to synthetic formulations for the treatment of mouth ulcer.
How to cite this article: Shaikh S, Shete A, Doijad R; Formulation and Evaluation Pharmaceutical aqueous gel of powdered Guava Leaves for Mouth Ulcer Treatment; PharmaTutor; 2018; 6(4); 32-38; http://dx.doi.org/10.29161/PT.v6.i4.2018.32
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REFERENCES:
1. Allen L. Compounding Gels, Current & Practical Compounding Information For The Pharmacist, 4(5), PaddocLaboratorits.
2. Blois, Antioxidant determination by the use of stable free radical Nature, 1958, 181(4617), 1199-1200.
3. Bhramaramba, Formulation and Evaluation of Herbal Gel Containing Terminalia chebula Retz Leaves Extract, Scholars Academic Journal of Pharmacy, 2015, 4(3), 172-176.
4. Dosani, Formulation Development And Evaluation of unit Moulded Herbal Semisolid Jelly Useful In Treatment Of Mouth Ulcer, International Journal of PharmTech Research, 2011, 3(3), 1705-1013.
5. Das S. et al, Formulation and Evaluation of Herbal Gel Containing Clerodendronin fortunatum Leaves Extract, International Journal of PharmTech Research, 2011, 1(3), 140-143.
6. Dwivedi S et al, Formulation And Evaluation of Herbal Gel Containing SesbaniaGrandiflora (L.) Poir. Leaf Extract, Acta Chimica & Pharmaceutica India, 2012, 1(2), 54-59.
7. Deepa, Ethnomedicinal Practices for Oral Health and Hygiene of Tribal population of Wayanad Kerala, International journal of Research in Ayurveda & Pharmacy, 2011, 2(4), 1246-1250.
8. Jose Ethno medicinal Herbs Used in Oral Health and Hygiene in Coastal Dashing Kannada, Journal of Oral Health Community Dentistry, 2011, 5(3), 119-124.
9. Gupta, Formulation and Evaluation of Topical Gel of Diclofenac Sodium Using Different Polymers, Drug Invention Today, 2010, 2(5), 250-253.
10. Jaiswal J, Formulation and Evaluation of Thermo reversible In-Situ Nasal Gel of Metoprolol Succinate, 2012, 4(3), 96-102.
11. Jadhav VD, Formulation and Evaluation of Herbal Gel Containing Leaf Extract of TridaxProcumbens, Journal of Pharmaceutical and Biosciences,2015, 3(2015), 65-72.
12. Kaur LP et al, Topical Gel: A Recent Approach for Novel Drug delivery, Asian Journal of Biomedical and Pharmaceutical Sciences, 2013, 3(17), 1-5.
13. Koland M, In vitro and in vivo evaluation of chitosan buccal films of ondansetron hydrochloride, International Journal of Pharmaceutical Investigation, 2011, 1(3), 164–171.
14. Mathangi , DPPH Free Radical Scavenging Activity of the Extracts of the Aquatic Fern Marsileaquadrifolia Linn, International Journal of Current Microbiology and Applied Science, 2013, 2(10), 534-536.
15. Nagi, Role of Medicinal Herbs in Management of Oral Diseases – A Review, IOSR Journal of Dental and Medical Sciences, 2015, 14(8), 40-44.
16. Pawar DP, Formulation And Evaluation of Herbal Gel Containing Lantana Camara Leaves Extract, Asian Journal of Pharmaceuticals & Clinical Research, 2013, 6(3), 122-124.
17. Pandey, Formulation And Evaluation of Invitro Antimicrobial Activity of Gel Containing Essential Oils And Effect of Polymer on Their Antimicrobial Activity, International Journal of Pharmacy And Pharmaceutical Sciences, 2011, 3(1), 234-237.
18. Singh M et al, Formulation and Evaluation of Herbal Gel Containing Ethanolic Extract of Ipomoea Fistulosa, International Journal of Science and Research, 2014, 3(7), 1862-1866.
19. NB Da Silva, Invitro Antimicrobial Activity of Mouthwashes and Herbal Products against dental biofilm- Forming bacteria, Contemporary Clinical Dentistry, 2012, 3(3), 302-305.
20. Sanghavi, Study on Topical Piroxicam Formulations, Indian Drugs, 1989, 26(4), 165-168.
21. Shivhare, Formulation Development and Evaluation of Diclofenac Sodium Gel Using Water Soluble Polyacrylamide Polymer, Digest journal of Nanomaterial’s and Biostructers, 2009, 4(2), 285-290.
22. Wang, Chemical Components and Bioactivities of Psidiumguajava, International Journal of Food Nutrition and Safety, 2014, 5(2), 98-114.
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