The St. John's Research Institute (SJRI) is a part of the St John's National Academy of Health Sciences, which is run by the CBCI Society for Medical Education. From its inception, St. John's has set before it an ideal of excellence in academic courses as well as service to society as a result of which it has truly become holistic both in its outlook and in its approach to the problems of community health. In 2000, the Academy decided that its commitment to excellence in research required the setting up of an Institute that was dedicated to the pursuit of research and capacity development in St. John's. This vision encompassed improvement of health of the community and patients through research and development of a Center for Excellence in medical research in India.
Post : Project Associate -II -DBT INDIGO Project
No. of Vacancy : One
Employment status : Contract
Salary : Rs. 35000+24%HRA for 2+ years experience +CSIR-UGC NET/GATE
Rs.31000+24%HRA Per Month for 0-1 years experience+CSIR-UGC NET/GATE
Rs. 28000+24% HRA for 2+ years experience
Rs.25000+24%HRA for 0-1 years experience
Language : English
Experience : Minimum experience of 0-2 years in R&D in industrial and academic institutions or science and Technology organisations and scientific activities and services is desirable
Preferred Qualifications : Master’s degree in Natural Sciences or Bachelor’s Sciences in Engineering or Technology or Medicine from recognised University And/ OR Scholars who are selected through National eligibility tests CSIR-UGC NET including lectureship or GATE or selection process through National level examinations conducted by central government department and their agencies and institutions.
Location : Bangalore
Brief Description about the Project
Despite the availability of flu vaccines for decades, influenza is still an important disease in both developing and developed countries with 500,000 casualties annually and many more people affected. From a global health perspective, the lack of effectivity, availability, affordability and accessibility of flu vaccines significantly limits our ability to respond to the seasonal flu every year and in the event of a pandemic. Currently, a low vaccine effectivity of 40% implies that 60% of vaccinated people are not sufficiently protected, with low confidence further contributing to limited uptake/immunization. In this project, public and private R&D organizations in India, EU and US collaborate on the development of two novel influenza vaccine concepts that meet the requirements of global vaccination, aiming to achieve <10% instead of 60% non-responders, lower costs, and better accessibility.
The first approach combines a low dose of a commercial, inactivated, seasonal flu vaccine with a novel, potent adjuvant, and will deliver proof-of-concept in Phase I and IIa trials within 5 years.
The second approach builds on three innovations :
1) A novel recombinant HA with increased immunogenicity,
2) A potent adjuvant,
3) An easy, needle-free delivery by intradermal patches.
Contra-productive parts of HA will be removed to increase the immunogenicity of neutralizing epitopes. The adjuvant further stimulates protective immunity and immunological memory. The use of intradermal patches opens possibilities for self-administration, which will improve vaccine uptake in developing as well as developed countries. With proven nonclinical immunogenicity and safety, we will embark on clinical development of this concept after completion of the project. These plans differ in complexity and timelines but are realistic with chances to deliver next-generation flu vaccines for the globe.
Roles & Responsibilities
• To conduct primary research as per the INDIGO award, including research towards stated goals and exploratory research within the confines of the INDIGO award in consultation with Dr Vyakarnam.
• Execute on multi-colour flowcytometry with advanced proficiency.
• Lead development, optimization, qualification, and validation of B and T-cell assays.
• To work under supervision of Lead Project Scientist of INDIGO project in set up of immune assays.
• To undertake key scientific administrative duties in placing ordering and maintaining an overview of expenditure
• To communicate work plan and data in weekly scientific laboratory meetings
• To undertake scholarly research activities such as scientific literature analysis and to show keenness to keep abreast of the current field and to effectively communicate academic thinking.
• To undertake scholarly research activities such as scientific literature analysis and to show keenness to keep abreast of the current field and to effectively communicate academic thinking
Interested candidates may send their Resume to :
The Principal Investigator
DBT INDIGO Study Project
SJRI
To Apply : E-mail cover letter and curriculum vitae with 3 references (names and email addresses / phone numbers) by on or before 9th November,2024 yashashwini@sjri.res.in & cc to hr@sjri.res.in
Last Day for Receiving Application : 9th November, 2024
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