Applications are invited for the PhD position to work in an Indo-Australian BITS-RMIT joint PhD programme under the supervision of Professor Swati Biswas, Department of Pharmacy, BITS-Pilani Hyderabad Campus, India & Dr. Sampa Sarkar.
Project Title : Development of surface-decorated lyotropic liquid crystalline drug delivery systems with various lipids/surfactants and optimization of their phase change behavior for superior wound healing application
Project ID : BITS025F001480
Eligibility : • M.Pharma in Pharmaceutics and M. Tech in Biotechnology
Desirable Criteria : GPAT is desirable but not mandatory Working Experience in the area of advanced drug delivery systems, cancer, bacterial study, protein purification, and recombinant DNA technology using plasmid vectors is desirable.
Highlights
• Acquire an internationally recognized qualification from an Indian Institute of Eminence University and a top Australian university • Receive a full RMIT tuition fee scholarship for the duration of your enrolment.
• Receive a generous scholarship with nominal tuition fees from BITS.
• Benefit from the combined expertise of two leading universities and access world-class research facilities in India and in Melbourne
• Travel to Australia for up to one year of candidature and be supported by an Australian stipend for the duration of your time in Melbourne
Project Description
Lyotropic liquid crystals (LLC) are self-assembled structures formed by amphiphilic molecules in water and exhibit various mesophases, such as lamellar, cubic, and hexagonal, depending on the lipid composition and water content. The application of LLCs in wound healing is emerging due to the unique properties of LLCs, which exhibit drug delivery, tissue engineering, bio-adhesion, and moisturization, as well as impart optimum viscoelastic properties for ease of application and spreading. In our work, we aim to develop hydrogel-based LLCs using various lipids and surfactants and study their phase-change behavior amenable for wound application. LLCs will be prepared using monoolein as a lipid, which can self-assemble into cubic, hexagonal, and lamellar phases, and surfactant, including poloxamers, span, tween, lecithin, and any PEGylated surfactants for surface decoration. The microfluidization technique will be used to prepare cubosomes and surface decoration will be executed to impart multifunctionality, including nanozyme incorporation and oxygen-release property by incorporating inorganic manganese oxide nanoparticles.
Project Deliverable / Outcomes
The liquid crystalline LLC-metallic hybrid will demonstrate optimal spreading ability on the wound, nanozyme-mediated antibacterial and manganese dioxide-mediated oxygen generation potential suitable for overcoming tissue hypoxia leading to necrosis. The formulation will be evaluated in the diabetic wound healing model.
Application Deadline : 3rd April 2025
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