Sanofi, in the U.S. and Canada, strives to create a diverse and inclusive work environment that empowers employees to drive their careers and be successful. The talent we look for will contribute to the organization in innovative, insightful, and creative ways in order to strengthen our dynamic culture and drive us collectively to make a difference in the lives of patients.
Post : Scientist
POSITION OVERVIEW/KEY RESPONSIBILTIES*:
Candidate will contribute directly to the development, improvement, and management of vaccines including viral vaccines, recombinant protein vaccines, and virus like particles. As a member of the Analytical Formulations team, the candidate will develop and optimize analytical assays to characterize vaccine targets, design experiments and studies to trouble shoot and investigate protein stability, and analyze and trend data for vaccine life cycle management. Candidate will accomplish these tasks in a laboratory setting and through collaborations both internal and external.
Responsibilities :
• Develop assays to monitor manufacturing processes and characterize proteins and vaccines using biophysical methods and techniques such as Surface Plasmon Resonance (SPR), Differential Scanning Fluorometry (DSF), Bi-layer Interferometry (Octet), Infrared spectroscopy (IR), Capillary Electrophoresis (CE), and Ultra Performance Liquid Chromatography (UPLC), and Circular Dichroism Spectroscopy; and transfer newly developed assays to other departments as needed.
• Design and execute studies to evaluate changes to manufacturing processes, equipment and/or site, and to evaluate the stability of novel protein candidates.
• Identify stability and formulation issues and evaluate potential solutions and improvements independently.
• Function as a lead and subject matter expert in investigations to support vaccine development and manufacturing.
• Participate on cross-functional teams to manage and facilitate projects.
• Manage and train analysts on procedures and systems.
• Adhere to company policies and maintain documentation and records of laboratory data and results.
• Provide and write status updates, status reports, assessments, development reports, procedures, and publish manuscripts in peer reviewed journals where appropriate.
• Maintain a knowledge of the scientific literature.
• Present ideas, concepts, and findings internally and externally and represent the company at national and international scientific conferences.
Candidate Profile
- MS or Ph.D. degree in Biochemistry or relevant field including Biophysical Chemistry, Biology, Pharmacy, Biomedical Engineering or combination of experience and training that is equivalent. 8-10 years of experience with MS, 2-5 years of experience with Ph.D.
- 2-5+ years of hands on experience in the characterization of vaccines and biologics in a pharmaceutical or biotechnology industry setting preferred.
- Experience in biophysical and biochemical characterization of proteins and a familiarity with state of the art biophysical and biochemical assays such as DSC, DLS, DSF, Bi-layer Interferometry, and UPLC is a plus.
- Familiarity with cGMPs and/or vaccine manufacturing is a plus.
- Experience in managing multiple projects and laboratory personnel.
- Excellent verbal and written communication skills.
Additional Information:
Experience: 8-10 years
Qualification: MS or Ph.D
Location: Meriden, CT
Job ID : R2449117
Functional Area: R&D
Industry Type: Pharma
End Date: 30th April, 2018
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