Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngenes clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife.
Associate Scientist (28928)
Required Qualifications :
• M.Sc/M.Tech/M.Phil in Stem cell biology/Cell biology or any other related field.
• Extensive experience (2-6 years) in hESC/iPSCs derivation, handling, propagation, characterization, and their functional assays.
• Demonstrated ability in managing projects in a multi-disciplinary environment to lead cross-functional activities
• Excellent communication (both written and oral), time management, record keeping and data analysis skills
Technical skills :
• Candidate must have experience in reprogramming strategies (integrated Vs non-integrated vector based/ Small molecule Vs mRNA based) used in reprogramming mature cells into iPSCs.
• Broad experience with iPSCs derivation (feeder-based Vs feeder free), propagation, expansion, characterization and cryopreservation.
• Experience at differentiation of iPSC lines into various lineages of cells.
• Good hands on experience at transfection/ transduction of immune and/or non-immune cells.
• Sound knowledge of microscopic imaging (Immunohistochemistry).
• Experience with flow cytometry is highly desirable, but not a prerequisite.
• Should be able to culture, expand, cryopreserve Mouse embryonic fibroblasts (MEFs) and/or Mouse bone marrow stromal cell lines as a part of day to day activities.
• Should be well verse flowcytometry based cell phenotyping
• Experience with Artificial Thymic Organoid culture (ATOC) is a plus, but is not a prerequisite.
• Previous experience of deriving iPSC lines from immune cells in an academic or industry setting is a plus.
• Must be well verse with aseptic techniques and good cell culture practices.
• Advanced computer proficiency including the use of spreadsheet and word processing software, such as Microsoft Word and Excel, GRAPH PAD.
Data Compilation skills :
• Computer proficiency including the use of spreadsheet and word processing software (such as Microsoft Word and Excel and Power point) and Image J or related software.
BEHAVIORAL SKILLS :
• Good work ethics with eye on detail.
• Good interpersonal skills, and the ability to work effectively in a team environment. Ability to work with co‐workers professionally.
• General ability to thrive in a growing infrastructure and culture and think out of box approach when troubleshooting and problem solving.
Associate Scientist- Cell and Assay Biologist 1 (29685)
Job Purpose :
To be a part of the Assay Biology and Screening group and support various assay development activities.
Key Responsibilities:
• To develop cell-based assays- optimization and assay validation in 96- and 384-well formats using different technologies
• Biochemical, Enzyme based assay development
• Screening of the compounds- small and large molecules.
• Data analysis, contemporaneous documentation and report preparation
• Interacting and presenting the data to the clients wherever needed
• Possess the knowledge and exposure to environment, health, and safety (EHS) practices
• Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety.
Educational Qualification:
• M.Sc/M.Tech/M.Pharm in Biological Sciences/ Biochemistry/ Biotechnology/ Cell Biology
Technical/functional Skills:
• Experience with conducting assays in 96-well and/or 384-well formats
• Experience with screening compounds in the dose-response formats for determining the potency of the compounds.
• Experience in conducting TR-FRET, HTRF, Fluorescence Intensity, Alpha screen, Radioactive assays OR Luminesce based assay.
• Expertise and in-depth knowledge of mammalian cell culture, with primary cells (hepatocytes, nerve cells or stem cells) and cancer cell lines
• Experience in different cell based assays viz. cytotoxicity assays, cytokine release assays, qPCR, Western blots is required
• Experience with spheroid cultures and 3D models would be desirable
• Experience in Flow cytometry and immune-phenotyping would be desirable
• Ability to analyze and present data using GraphPad Prism; MS Excel, ppt and statistical tools
• Willingness and flexibility to work in cross functional teams across technical domains
• Ability to plan and execute work and perform multiple activities in parallel.
Experience:
• M.Sc/M.Tech or M.Pharm with 2 to 9 years of experience
Behavioral Skills
• Good work ethics.
• Good interpersonal skills, and the ability to work effectively in a team environment.
• Ability to work with co‐workers professionally.
• General ability to thrive in a growing infrastructure and culture and also think out of box approach when troubleshooting and problem solving.
Job Location : Bengaluru
Date/Time : 16th June’21, Wednesday, 4:30 PM onwards (MS Teams link will be shared with the shortlisted candidates, one day prior)
Please apply using the above links or write to megha.paniker@syngeneintl.com
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