Translational Health Science and Technology Institute (THSTI) is an autonomous Institute of the Department of Biotechnology (DBT), Ministry of Science and Technology, Govt, of India. The institute is an integral part of the interdisciplinary NCR Biotech Science Cluster (NCR BSC) located at Faridabad, and is designed with the mission to conduct innovative translational research to translate concepts into products to improve human health. We are in the process of filling up vacancies in the project entitled “Translational Research Program” and other related projects.

Technical Manager (Bioassay Lab)
No of posts : 01
Max Monthly consolidated emoluments : Upto Rs. 1,00,000/-
Age Limit : 40 years
Minimum Qualifications & Experience : Post graduate degree with 7 years of experience in GLP/NABL-accredited biology laboratories with extensive experience in establishment of assays such as ELISA, genotyping, serotyping, qRT - PCR. At least 3 years (out of 7 years) experience as a team lead in a GLP laboratory or a NABL (or any other national international accreditation - accredited laboratory for vaccines or biologicals. (Candidates with a doctoral degree with relevant experience may also apply)
Essential:
Hands-on experience in validation of assays, quality control and quality assurance processes for accreditation. Sound knowledge of regulatory processes for assays used in diagnostics and vaccine development.
Desirable : Knowledge and experience in Microbiology, Virology, Molecular biology and animal cell culture.
Domain and Job Description : Bioassav Lab : The Technical Manager will be reporting to the laboratory director and will be responsible for the following:
* Day-to-day functioning of the bioassay laboratory.
* Supervising the activities of a team of junior colleagues consisting of technical officers, lab technicians and lab attendants.
* Involved in establishing new assays, in monitoring the performance of the existing assays as per the regulatory guidelines for vaccine research.
* Ensuring compliance with accreditation processes (ISO - 17025 and ISO-15189).
* Provide assistance in the preparation of documents, verification of documents for
regulatory compliance.
* Verification of assays using reference reagents and
* Training of team members.

Technical Manager (Grants Coordinator)
No of post : 01
Max Monthly consolidated emoluments : Up to Rs. 1,00,000/-
Age Limit : 40 years
Minimum Qualifications & Experience : Post graduate degree with 7 years of experience as a scientific administrator in national/ international academic institutions. At least 3 years’ (out of 7 years) experience in Managing grant-in-aid operations and human & animal ethics compliance.
Domain and Job Description :
• The incumbent will be responsible for developing and streamlining the institutional operations for receiving grants-in-aid and for supporting maintenance of ethical compliance in the life cycle of research grants.
• The incumbent will support all the investigators in the pre-award, award and post-award phase. The appointee will be the point person for grant-in-aid operations and will work in close coordination with the core administration.
• The incumbent will be responsible for operations of the ethics secretariat, advising investigators about submission to institutional ethics committees, coordinating the activities of the institutional ethics committees, (Human Participants, Stem-Cell and Animal Ethics), alerting investigators about new regulations.

Senior Technical Officer
No of post : 03
Max Monthly consolidated emoluments : Up to Rs. 85,000/-
Age Limit : 35 years
Minimum Qualifications & Experience : Post graduate degree in Life Sciences/ Chemical Sciences/ Pharmaceutical Sciences/ Computer Science/ Information Technology/ Engineering/ Bioinformatics or in relevant area with 7 years of experience in the relevant field.
Domain and Job Description :
Infectious diseases and immunology [l&l]/ Multi-disciplinary clinical and translational research [MCTR]/ Non¬communicable diseases [NCD] / Bioassay Laboratory [BAL]/ Biorepository Facility [BRF]/ Data Management Centre [DMC]/ Small Animal Facility [SAF]

THSTI comprises of four major research themes and four core facilities.

a) The four major research themes for the new research and development program are:

i) Infectious diseases and immunology [l&l]
The focus is on drug and vaccine development for infectious diseases. Specific objectives of this area are:
• Discovery and validation of therapeutics for tuberculosis and other infectious diseases
• Late stage vaccine development for diseases of public health interest in India
• Pathogen phylogenetics
• Deep immunophenotyping of humans challenged with vaccines or infectious agents
• Establishment of proof-of-principle for microbiome-based interventions in
i) inflammatory bowel disease and ii) pre-term birth

ii) Maternal and child health [MCH]
• Maternal and child health research at THSTI encompasses molecular studies in perinatal biology, maternal nutrition and other aspects relevant to maternal and child health.
• Understand feto-placental development and in utero placental dysfunction and association with pregnancy outcomes
• Long term outcomes in growth-restricted fetuses and preterm babies
• Environmental determinants of pregnancy outcomes
• Develop tools to measure nutrient status
• Biology of nutrition and evaluation of interventions

iii) Multi-disciplinary clinical and translational research [MCTR]
This area is focused on development of diagnostics for infectious diseases, antimicrobial resistance and snake-bite and following objectives have been identified:
• Highly sensitive semi-quantitative point-of-care tests (POCT) for blood-borne virus screening and for acute febrile illnesses
• Rapid tests for Antimicrobial Susceptibility Testing
• New approaches to identification of snake venom/bites

iv) Non-communicable diseases, with a focus on Diabetes and NASH [NCD]
Multidisciplinary approaches to address unmet needs of target discovery and validation, identification of stage-specific biomarkers for diagnosing disease progression using animal models and development and validation of prediction tools. Current focus is on:
• Tool for diabetes prediction based on metabolomic signatures using machine learning algorithms
• In vitro and in vivo models of non-alcoholic fatty liver disease (NAFLD), to evaluate new chemical entities (NCEs) and plant-based extracts to identify therapeutic leads
• Stage-specific molecular signature for diagnosis/ prognosis of dyslipidemia, inflammation and fibrosis associated with NAFLD/NASH.

b) The four thematic areas will be supported by four core facilities that will serve not only the research programmes of THSTI, but also cater to the NCR-BSC and other academic and industrial partners.

i) Bioassay Laboratory [BAL]
The bioassay lab was established in 2018 with the goal of ISO accreditation by the National Accreditation Board for Testing and Calibration Laboratories. Candidate viral vaccines are being developed in India and will require clinical trials from Phase I to Phase III. BAL will act as a GCLP facility to support these clinical studies by providing assay platforms for various clinical and immunological assays.

ii) Biorepository Facility [BRF]
The biorepository (Rakshita) is a bio-bank for facilitating national and international collaborations on translational research in maternal and child health. The biorepository is continuously expanding with samples being collected at collaborating hospitals and sent to
THSTI.

iii) Data Management Centre [DMC]
A state-of-the-art data management centre is currently augmenting the data management capability and capacity of investigators working on research projects that require management of enormous amount of data collected through clinical studies, cohort studies and large multicentre studies being led / coordinated by THSTI investigators. The DMC provides support for statistical analysis to groups at THSTI and outside.

iv) Small Animal Facility [SAF]
The Small Animal Facility (SAF) breeds and maintains genetically defined inbred strains of rats and mice and has a specialized animal biosafety containment facility for undertaking animal research for infectious diseases. Future upgradation for development of transgenics and new models is underway.

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Note 1 : Those willing to apply for the above scientific positions are required to identify their area of expertise from amongst the three themes namely l&l, NCD or MCTR or core facilities namely BAL, BRF, DMC and SAF and other areas relevant with the mandate of THSTI explaining in 1000 words how they will be able to contribute to the thematic area / core facility towards the project.

Note 2 : Shortlisting Criteria- Candidates who fulfill the qualification and relevant experience required for the research theme/core facility for which the application is submitted and whose proposal is found to be relevant will only be shortlisted for further selection process.

Note 3 : Award of marks for selection process:
Assessment Criteria
Proposal : 40
Interview and Presentation : 60
Total Marks : 100

Note 4 : The selection committee may recommend a candidate for lower grade/pay based on the qualification, skills and experience of the candidate.

General Terms & Conditions:
1. Appointment will be made on yearly contract basis for a period of three years (extendable to five years) with an initial probation period of six months that may be extended at the discretion of the competent authority.
2. All educational, professional and technical qualification should be from a recognized Board/University.
3. The experience requirement specified shall be experience acquired after obtaining the minimum educational qualifications required for the post.
4. Persons working in Govt. / PSUs / autonomous bodies should apply through proper channel or produce a relevant ‘No Objection Certificate’ at the time of Interview. Such employees will be considered for appointment on direct recruitment /deputation/ short term contract basis. The educational qualification and experience shall be the same and the terms and conditions of deputation shall be governed by DoPT OM No. 6/8/2009-Estt. (Pay II) dated 17th June 2010.
5. Age and other relaxations for direct recruits and departmental candidates: 1. By 5 years for candidates belonging to SC/ST communities. 2. By 3 years for candidates belonging to OBC communities. 3. For Persons with Disabilities (PwBD) falling under the following categories: (i) UR -10 years , ii) OBC -13 years (iii) SC/ST -15 years 4 For Ex-servicemen upto the extent of service rendered in defence forces (Army, Navy & Air force) plus 3 years provided they have put in a minimum of 6 months attested service.. 5. Relaxation of 5 years will also be permissible to those who had ordinarily been domiciled in the Kashmir division of the State of Jammu and Kashmir during the period from 01/01/1980 to 31 /12/1989 subject to production of relevant certificate from concerned authority.

6. Age is relaxable for Government servants up to 5 years in accordance with the instructions or orders issued by the Central Government, from time to time. 7. There is no upper age limit for the employees who are working for THSTI. 6. The closing date of online application will be the CRUCIAL DATE for determining eligibility with regard to age, essential qualification etc.
7. One candidate can apply for only one position.
8. The positions advertised will be filled only if suitable candidates are identified.
9. Outstation SC/ST/ PwBD candidates called for the interview will be paid to & fro second class railway fare, as per Govt, of India rules on production of the proof of the same.
10. All results will be published on our website and all communications will be only through email.

Check the following before submitting the application:
To ensure that your application is not rejected, confirm the following:
(i) You fulfill the educational qualification and age criteria provided for each position.
(ii) You fulfill the relevant experience as specified under para [3].
(iii) You have enclosed experience certificates to prove that you have experience mentioned under para [3].
(iv) You fulfill all conditions specified for filling up of online application.
In case of non-fulfillment of any of the above requirements, the application will be rejected

Procedure for filling online application:
a) Before filling up the online application, keep the following documents handy:
A soft copy of your passport size photo and signature, (only jpeg/jpg/png format)
A comprehensive CV (PDF format only) containing details of qualification, positions held, professional experience/distinctions etc.

The documents in support of educational qualification and experience (PDF format only) as mentioned below:
* Matriculation Mark sheet Intermediate Mark sheet Graduation Degree/Mark Sheet Post-* Graduation Degree/Mark Sheet Ph.D/MD or equivalent degree(if any)
* Relevant experience certificates
* Caste/Disability certificate in the format prescribed by the Govt, of India, if applicable List of Publications (if any)
* List of patents (if any)
* Write-up (not exceeding 500 words)

iv) Application fee is to be deposited online as per details given below:
Unreserved candidates/EWS/OBC : 500
SC/ST/Women/PwBD : Nil
After submitting the application, you will be automatically redirected to the dashboard wherein you will be required to click on “Pay Online” button in order to proceed for payment.
• The payment can be made by using Debit Card/Credit Card/lnternet Banking/UPI.
• Once payment is made, no correction/modification is possible.
• Candidates are requested to keep a copy of provisional receipt for future reference.
• Fee once paid shall not be refunded under any circumstances.

b) The eligible and interested candidates may apply online. Applications through any other mode will not be accepted.
c) On successful submission of your application, an auto-generated email containing the reference number will be sent to the email address provided. Please keep a note of the reference number for future correspondence.
d) Candidates are required to keep a printout of the online application form by using the print button on the dashboard for future reference.
e) Candidates must ensure that he/she fulfils all eligibility criteria as stipulated in the advertisement. If it is found that he/she does not fulfil the stipulated criteria, the candidature will be cancelled.
f) Incomplete applications shall be summarily rejected and no correspondence in this regard shall be entertained.
g) Candidates are requested to use Google Chrome internet browser for best results in submission of online application.
h) In case of difficulty in filling up the online form, please send e-mail to personnel@thsti.res.in .

Important Date
Last date for receipt of online application : 10th February 2020