The University of Oxford is a complex and stimulating organisation, which enjoys an international reputation as a world-class centre of excellence in research and teaching. It employs over 10,000 staff and has a student population of over 21,000.
Most staff are directly appointed and managed by one of the University’s 130 departments or other units within a highly devolved operational structure - this includes 5,900 ‘academic-related’ staff (postgraduate research, computing, senior library, and administrative staff) and 2,820 ‘support’ staff (including clerical, library, technical, and manual staff). There are also over 1,600 academic staff (professors, readers, lecturers), whose appointments are in the main overseen by a combination of broader divisional and local faculty board/departmental structures. Academics are generally all also employed by one of the 38 constituent colleges of the University as well as by the central University itself.
Post: Postdoctoral Research Scientist - Chemical Biology
Division: Medical Sciences
Department: NDM Research Building ,Nuffield Department of Clinical Medicine (NDM)
Grade and salary: Grade 7, £30,738 - £37,768 p.a.
Vacancy reference 121864
Medical Sciences:
The Medical Sciences Division is an internationally recognized centre of excellence for biomedical and clinical research and teaching. We are the largest academic division in the University of Oxford World - leading programmes, housed in state - of - the - art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care.
Overview of the role:
The Chemical Biology group is seeking a highly motivated Postdoctoral Scientist to work on the identification of novel drug targets and therapeutic options for the treatment of multiple myeloma. The position is funded by the Structural Genomics Consortium Company and Myeloma UK (MUK) and is available for 2 years .
The research programme will involve collaborations with other MUK - funded groups and have an initial emphasis on target identification in disease - relevant model systems.
Candidates should have extensive experience in chemical biology and/or functional genomics with practical experience in target identification and preclinical biomarker discovery/validation for cancer drug discovery.
You will be a self - motivated, enthusiastic and skilled scientist with a strong academic track record . You will work in a multidisciplinary team and therefore require strong communication skills
Responsibilities/duties:
1.Design, establish and conduct genomic and/or small molecule screens in relevant tumour models for myeloma to identify new drug targets and drug synergies.
2.Set up orthogonal cell based assays to validate identified targets/active compounds
3.Contribute to the elucidation of the functional role of identified targets or active drugs and drug combinations.
4.Engage in the further development and optimisation of active compounds and potential therapeutic biomarkers.
5.To keep up to date with the relevant scientific literature.
6.To work independently and as part of a team to complete research projects and draw conclusions from analysing all available data.
7.To demonstrate excellent scientific skills and actively contribute to scientific publications of key results.
8.To present data both internally and at scientific meetings to publicise the work of the group.
9.To keep complete, accurate and up to date records of all experimental results.
10.To carry out any other relevant duties as may reasonably be associated with the post and which may be required from time to time.
11.To participate in and support the public engagement and widening access activities of the Department and the University. This is anticipated to be not more than 2 days per year.
Selection criteria:
Please ensure you provide a detailed covering letter explaining why you are interested in this position, and how you meet each of the criteria below with examples.
Essential:
-PhD in biology, chemistry or pharmacology.
-Excellent academic publication track record or an equivalent combination of trainingand experience.
-Strong background in chemical biology including targetidentification or drug discovery with practical experience in either chemical proteomics and target validation or genetic screens using RNAi and CRISPR.
-Demonstrate enthusiasm, motivation, integrity, flexibility and confidence.
Good communication and interpersonal skills: ability to work both independently and aspart of a team, with potential to take on supervisory responsibilities.
-Excellent oral presentation and written communication skills including experience in independently writing scientific report s and manuscripts.
-Knowledge of appropriate Health & Safety procedures, observe local codes of practice and observe and if necessary write COSHH assessments for all procedures used.
Desirable:
Experience in myeloma biology
Experience in drug development
Experience in bioinformatics data analysis (proteomics, RNA-seq)
Experience in cellular/tissue assay development
How to apply:
If you consider that you meet the selection criteria, click on the Apply Now button on the ‘Job Details’ page and follow the on-screen instructions to register as a user. You will then be required to complete a number of screens with your application details, relating to your skills and experience. When prompted, please provide details of two referees and indicate whether we can contact them at this stage. You will also be required to upload a CV and supporting statement. The supporting statement should describe what you have been doing over at least the last 10 years. This may have been employment, education, or you may have taken time away from these activities in order to raise a family, care for a dependant, or travel for example. Your application will be judged solely on the basis of how you demonstrate that that you meet the selection criteria outlined above and we are happy to consider evidence of transferable skills or experience which you may have gained outside the context of paid employment or education. Please save all uploaded documents to show your name and the document type.
All applications must be received by midday on the closing date stated in the online advertisement
The closing date for this position is 12.00 noon on Wednesday 17 February 2016.
See All B.Pharm Alerts M.Pharm Alerts B.Sc Alerts
See All Other Jobs in our Database
.png)
