Syngene International Ltd is an integrated research, development and manufacturing services company serving the global pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical sectors. Syngene’s 4500+ scientists offer both skills and the capacity to deliver great science, robust data management and IP security and quality manufacturing, at speed, to improve time-to-market and lower the cost of innovation.
Post : Sr Research Associate
he candidate should have an excellent understanding of the fundamentals of drug metabolism and pharmacokinetics principles and drug discovery; prior experience in progressing a project from hit identification to lead optimization is a plus.
Req ID 53710 – Senior Research Associate – Invitro ADME (Cell Culture)
Job Description :
• Overall adherence to safe practices and procedures of oneself and the teams aligned.
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards.
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
• Compliance to Syngene’ s quality standards at all times.
• Support the ADME team by conducting the Caco-2, LLC-PK1-MDR1, MDCK-II-MDR1, MDCK-II BCRP transporter assays in 24 well/ 96 well plate transwell assays using different matrices with highest quality
• Contemporaneous recording of lab activities and experiments performed practices high level of housekeeping.
• Adhere to all safety rules and maintains safe workplace.
• Predominantly laboratory-based job
• Experience in handling cell culture activities
• Design and execute Caco-2, LLC-PK1-MDR1, MDCK-II-MDR1, MDCK-II BCRP transporter assays in 24 well/ 96 well plate transwell assays
• Reporting of executed studies without mistakes
• Preparation reports, eLN updation on time, reporting of study results clearly in the cross functional scientific meetings.
• Understanding and demonstrating responsibility for safety of self & colleagues by following all safety protocols provided by Syngene
• Adherence to all environment, health, and safety (EHS) policies & standards at all times in the workplace
• Wearing all PPE as required.
• Adherence to all procedures related to Syngene’s data integrity policies
• Compliance to Syngene’s quality standards at all times.
Req ID 53712 – Associate Scientist – Invitro ADME (Physchem + Plasma Protein Binding)
Job Description :
• Overall adherence to safe practices and procedures of oneself and the teams aligned.
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards.
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
• Compliance to Syngene’ s quality standards at all times.
• Support the ADME team by conducting the Physicochemical assays such as solubility, Log-D, Log P and binding studies with various matrices such as plasma, tissue homogenates with highest quality.
• Interact with cross functional scientific teams and external collaborators and remain as a subject matter expert in the field of ADME sciences
• Identification of new technologies to support highly demanding ADME sciences
• Time management and multi-tasking skills to meet the demand of high-volume wave 1 ADME assays to complete multiple projects within timelines.
• Contemporaneous recording of lab activities and experiments performed, practices high level of house keeping
• Adhere to all safety rules and maintains safe workplace.
• Predominantly laboratory-based job
• Extensive experience in planning Physicochemical assays such as solubility, Log-D, Log P and binding assays
• Design and execute Physicochemical assays such as solubility, Log-D, Log P and PAMPA
• Design and execute binding assays in plasma, microsomes, brain and tissue homogenates assay
• Seamless coordination with BA-DMPK group execute binding studies.
• Preparation of SOP’s and EOPs.
• Reporting of executed studies without any noncompliance.
• Reporting of study results clearly in the cross functional scientific meetings.
• Understanding and demonstrating responsibility for safety of self & colleagues by following all safety protocols provided by Syngene
• Adherence to all environment, health, and safety (EHS) policies & standards at all times in the workplace
• Wearing all PPE as required.
• Adherence to all procedures related to Syngene’s data integrity policies
• Compliance to Syngene’s quality standards at all times.
Req ID 53713 – Senior Research Associate – Invitro ADME (Physchem + Plasma Protein Binding)
Job Description :
• Overall adherence to safe practices and procedures of oneself and the teams aligned.
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards.
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
• Compliance to Syngene’ s quality standards at all times.
• Support the ADME team by conducting the Physicochemical assays such as solubility, Log-D, Log P and binding studies with various matrices such as plasma, tissue homogenates with highest quality.
• Interact with cross functional scientific teams and external collaborators and remain as a subject matter expert in the field of ADME sciences
• Identification of new technologies to support highly demanding ADME sciences
• Time management and multi-tasking skills to meet the demand of high-volume wave 1 ADME assays to complete multiple projects within timelines.
• Contemporaneous recording of lab activities and experiments performed, practices high level of house keeping
• Adhere to all safety rules and maintains safe workplace.
• Predominantly laboratory-based job
• Extensive experience in planning Physicochemical assays such as solubility, Log-D, Log P and binding assays
• Design and execute Physicochemical assays such as solubility, Log-D, Log P and PAMPA
• Design and execute binding assays in plasma, microsomes, brain and tissue homogenates assay
• Seamless coordination with BA-DMPK group execute binding studies.
• Preparation of SOP’s and EOPs.
• Reporting of executed studies without any noncompliance.
• Reporting of study results clearly in the cross functional scientific meetings.
• Understanding and demonstrating responsibility for safety of self & colleagues by following all safety protocols provided by Syngene
• Adherence to all environment, health, and safety (EHS) policies & standards at all times in the workplace
• Wearing all PPE as required.
• Adherence to all procedures related to Syngene’s data integrity policies
• Compliance to Syngene’s quality standards at all times.
Senior Research Associate - Invitro ADME (53714)
Job Description : • Overall adherence to safe practices and procedures of oneself and the teams aligned.
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards.
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
• Compliance to Syngene’ s quality standards at all times.
• Conducting microsomal metabolic stability, and CYP450 inhibition assays with highest quality
• Contemporaneous recording of lab activities and experiments performed practices high level of housekeeping.
• Adhere to all safety rules and maintains safe workplace.
• Predominantly laboratory-based job
• Execution of in vitro metabolic stability, and single point CYP P450 inhibition, reversible CYP P40 IC50 inhibition and TDI-IC50 shift assay.
• Preparation of SOP’s and EOPs.
• Reporting of executed studies without any compliance.
• Preparation reports, eLN updation on time, reporting of study results clearly in the cross functional scientific meetings.
• Understanding and demonstrating responsibility for safety of self & colleagues by following all safety protocols provided by Syngene
• Adherence to all environment, health, and safety (EHS) policies & standards at all times in the workplace
• Wearing all PPE as required.
• Adherence to all procedures related to Syngene’s data integrity policies
• Compliance to Syngene’s quality standards at all times.
Invitro ADME Bioanalyst (53743)
Job Description : • Optimization of test compounds and to develop high throughput, fit for purpose LC-MS/MS and HPLC-UV methods to support ADME samples analysis: Formulations analysis, solubility studies, stability studies, In vitro assays, MET ID and large molecule analysis etc.
• Perform analysis of samples generated for the screening of compounds for ADME assays and Processing of different matrices/formulation samples of PK studies with no/minimal supervision
• Excellent written and oral communication skills interacting with internal stakeholders
• Operation, maintenance and troubleshooting of HPLC/ LC-MS/MS system
• Preparation of protocols, reports and templates for responsible activities
• Instrument maintenance, scheduling calibration and maintaining documentation as per regulatory compliance and company policy
• Adhering to safety and quality policies laid by organization
• Delivery of quality data with planning, execution of bioanalytical activities within the team in agreeable timelines
• Development and implementation of high throughput, fit for purpose bioanalytical methods to support invitro ADME samples analysis
• Identification of problem and trouble shooting in quick turn-around time
• Mentoring team members to generate quality data within agreed timelines
• To perform MET ID studies and providing final quality data with interpretation
• Peptide/ large molecule bioanalysis
• Coordination with related invitro verticals to plan the bioanalysis in cassette
• Excellent written and oral communication skills interacting with internal/external stakeholders
• Operation, maintenance and troubleshooting of HPLC/ LC-MS/MS system
• Preparation of protocols, reports and templates for responsible activities
• Instrument maintenance, calibration and maintaining documentation as per regulatory requirements and company policy
• Adhering to safety and quality policies laid by organization
• Formulation analysis data review and trouble-shooting for quicker resolution
Senior Research Associate - Invitro ADME + Bioanalytical (53741)
Job Description : • Overall adherence to safe practices and procedures of oneself and the teams aligned.
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards.
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
• Compliance to Syngene’ s quality standards at all times.
• Bioanalytical scientist familiar in handling HPLC and support ADME screening assays: Formulations analysis, solubility studies, stability studies, ectc. and understanding of LCMS in line with business needs.
• Optimization of test compounds and to develop high throughput, fit for purpose HPLC-UV methods to support ADME samples analysis: Formulations analysis, solubility studies, stability studies, etc.
• Perform analysis of samples generated for the screening of compounds for ADME assays and Processing of different matrices/formulation samples of PK studies
• Good written and oral communication skills interacting with internal stakeholders
• Operation, maintenance and troubleshooting of HPLC/ LC-MS/MS system
• Preparation of protocols, reports and templates for responsible activities
• Instrument maintenance, calibration and maintaining documentation as per regulatory requirements and company policy
• Understanding and demonstrating responsibility for safety of self & colleagues by following all safety protocols provided by Syngene
• Adherence to all environment, health, and safety (EHS) policies & standards at all times in the workplace
• Wearing all PPE as required.
• Adherence to all procedures related to Syngene’s data integrity policies
• Compliance to Syngene’s quality standards at all times.
Invitro ADME BA vertical lead (53744)
Job Description : • Delivery of quality data with planning, execution of bioanalytical activities within the team in agreeable timelines
• Mentor a group of scientists for development and implementation of high throughput, fit for purpose bioanalytical methods to support invitro ADME samples analysis
• Identification of problem and trouble shooting in quick turn-around time
• Mentoring team members to generate quality data within agreed timelines
• To perform MET ID studies and providing final quality data with interpretation within agreed timelines
• Peptide/ large molecule bioanalysis
• Coordination with related invitro verticals to plan the bioanalysis in casette
• Excellent written and oral communication skills interacting with internal/external stakeholders
• Operation, maintenance and troubleshooting of HPLC/ LC-MS/MS system
• Preparation of protocols, reports and templates for responsible activities
• Instrument maintenance, calibration and maintaining documentation as per regulatory requirements and company policy
• Adhering to safety and quality policies laid by organization
• Formulation analysis data review and trouble shooting for quicker resolution
• Ensure data compliance as per company procedures
• Coordination with related invitro verticals to plan the bioanalysis in cassette
• Excellent written and oral communication skills interacting with internal/external stakeholders
• Operation, maintenance and troubleshooting of HPLC/ LC-MS/MS system
• Preparation of protocols, reports and templates for responsible activities
• Instrument maintenance, calibration and maintaining documentation as per regulatory requirements and company policy
• Adhering to safety and quality policies laid by organization
Principal Scientist - Invitro ADME + Bioanalytical (53745)
Job Description : • Overall adherence to safe practices and procedures of oneself and the teams aligned.
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards.
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
• Compliance to Syngene’ s quality standards at all times.
• Hold self and their teams accountable for the achievement of safety goals
• Govern and Review safety metrics from time to time.
• Bioanalytical scientist with expertise in handling, troubleshooting LCMS/MS, LCHRMS/MS, support ADME screening assays bioanalysis, MET ID, large molecule analysis by LCMS and ability to develop and implement new invitro bioanalytical techniques in line with business needs. The candidate should be able to handle a team of 12 to 15 scientists and should take care of all lab activities
• Delivery of quality data with planning, execution of bioanalytical activities within the team in agreeable timelines
• Lead and mentor a group of scientists for development and implementation of high throughput, fit for purpose bioanalytical methods to support invitro ADME samples analysis
• Identification of problem and trouble shooting in quick turn-around time
• Guiding team members to generate quality data within agreed timelines
• To perform MET ID studies and providing final quality data with interpretation within agreed timelines
• Peptide/ large molecule bioanalysis by LCMS/MS
• Ability to identify critical talents, train them in accordance with the organizational goals
• Coordination with related invitro verticals to plan the bioanalysis in cassette
• Excellent written and oral communication skills interacting with internal/external stakeholders
• Operation, maintenance and troubleshooting of HPLC/ LC-MS/MS system
• Preparation of protocols, reports and templates for responsible activities
• Instrument maintenance, calibration and maintaining documentation as per regulatory requirements and company policy
• Adhering to safety and quality policies laid by organization
• Formulation analysis data review and trouble-shooting for quicker resolution
• Ensure data compliance as per company procedures
• Coordination with related invitro verticals to plan the bioanalysis in cassette
• Excellent written and oral communication skills interacting with internal/external stakeholders
• Operation, maintenance and troubleshooting of HPLC/ LC-MS/MS system
• Preparation of protocols, reports and templates for responsible activities
• Instrument maintenance, calibration and maintaining documentation as per regulatory requirements and company policy
• Adhering to safety and quality policies laid by organization
• Formulation analysis data review and trouble-shooting for quicker resolution
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensuring that there are no safety non-compliances in areas that my team operates in.
• Ensuring adherence to all Syngene policies related to data integrity by all members of the team including self
• Ensuring all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self
• Reporting incidents (or near-misses) and learnings from those incidents to avoid recurrence.
• Compliance to Syngene’ s quality standards at all times and ensuring the same by the team members.
Qualification & Experience : MSc / MTech / MPharm / Ph.D. with 2 to 10 years of relevant experience (Freshers are requested not to apply)
Job Location : Hyderabad
WALK IN INTERVIEW
Date & Time for Registration : 12 Feb 2023, 9 AM to 10 AM.
Interview Venue : Minerva Grand Hotels – 7th Floor Hall, Bhuvana Towers, SD Road, Kalasiguda, Secunderabad, Telangana – 500003
Candidates need to have the following documents handy
Updated resume (Printed copy)
ID proof (PAN/Aadhaar card)
Double dose vaccination certificate
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