Piramal Life Sciences Limited (PLSL) is an independent research-driven drug company that was recently demerged from Piramal Healthcare Limited (Formerly known as Nicholas Piramal India Limited). PLSL was formerly the NCE R&D division of NPIL. PLSL has state-of-the-art R&D laboratories built over 200,000 square-feet of space in Mumbai, India and over 300 scientists engaged in drug discovery and development.
Post: Drug Metabolism & Pharmacokinetics - Senior Research Scientist
Job description
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Set-up and perform mass spectrometry-based comprehensive proteomic workflows including protein fractionation, 2D gel analysis, in-gel and in-solution sample preparation, protein ID, peptide mass fingerprinting, label-free quantification and data analysis. Further, integration of proteomic data with metabolomic and pharmacological information to support drug discovery and development
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Maintain and operate nanoLC-HRMS (high resolution mass spec), MALDI-TOF and UPLC-MS/MS instruments such as Q-Exactive Orbitrap and Q-TOF LC/MS. Also train and assist other team members
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Perform large scale MS data processing and mining using various software such as Proteome Discoverer, MassFrontier, MetAlign, R, Matlab, Mascot, Expressionist, SEQUEST etc
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Generation and maintenance of biological sample bank, metabolite and protein standards, spectral libraries and databases
Candidate Profile
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Independently execute high-throughput proteomic and metabolomic sample preparations for in-vitro and in-vivo biological samples
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Hands-on experience in operating and maintaining high resolution mass spec instruments
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Experience in application of proteomic technology for target discovery and studying cancer metabolism is highly desirable
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Should have strong communication, interpersonal and data presentation skills to coordinate with other drug discovery and development groups
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Having industrial experience in small molecule Metabolomics, pharmacokinetics, drug metabolism (Metabolite -ID) and in vitro assays using LC-MS will have an added advantage
Additional Information:
Experience: 0-5 years for Masters/ 0-3 years for Ph.D
Location: Goregaon, Mumbai
Industry Type: Pharma/ Biotech/Clinical Research
Functional Area: R&D
Education: M.Sc, M.Pharm, Ph.D
End Date: 26th March, 2014
In case you wish to apply to this position, please send us your CV
Applications may be sent to. research.recruitment@piramal.com
The subject line may read ' DMPK Proteomics - 001 '
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