Syngene is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply. At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures and SOPs, in letter and spirit.
Post : Synthetic & Medicinal Chemistry
Department : Discovery Chemistry
Job Location : Bangalore and Hyderabad
Qualifications : M.SC. / M Pharm / PhD. With 3+ years' experience
Medicinal Chemistry Scientist
Core Purpose of the Role
Personnel handling this profile will be responsible for performing reactions as per the requirement of the project. They are also responsible for documenting the observations in relevant note books. They are to follow instructions from the supervisor and work in a group (or individually) to accomplish the tasks in a timely and efficient manner
Role Accountabilities
• Perform synthetic chemistry reactions, reaction workups, purification of the compounds by column chromatography, crystallization, re-crystallization techniques, preparative TLC and operating lab equipment’s
• Ensure that the samples generated during synthesis are given for analysis and record subsequent results obtained and update the supervisor / group leader on the progress of synthesis and ensure samples are packed appropriately for shipment
• Record the observations of experiment/reaction, results, utilization of resources and other activities related to the reaction in the laboratory or e-notebook following guidelines and in timely manner and ensure that the same is handled safely and confidentially.
• Ensure that the instrument / equipment is calibrated, undergone preventive maintenance and are kept clean before use and in case of any breakdown, report to maintenance immediately
• Ensure that they know the MSDS of the chemicals they are handling and aware of emergency response procedures in case of accidental spillage, leakage or fire and ensure proper waste segregation as per EHS norms
• Always follow EHS and quality system requirements in the workplace ensuring individual safety and lab safety
• Attend all mandatory trainings and update training records as and when trainings are completed
• Always ensure confidentiality
Team / Project Lead
Job Purpose
The purpose of the role is to lead an Integrated Drug Discovery Project as a project leader
Key Responsibilities
• Provide strategic and scientific leadership to integrated drug discovery projects for our clients
• Liaise with the Functional Head - Medicinal Chemistry on projects priorities and ensure that project deliverables are met.
• As program leader supervise one/ three medicinal chemistry project(s).
• Analyze SAR and design new set of compounds using CompChem tools to address various MedChem issues.
• Provide regular updates on project progress to the Section Head - medicinal chemistry / Functional Leads and clients.
• Work collaboratively with the CADD scientists, biologists, DMPK scientists and the safety pharmacologists.
• Exceptional creativity and innovation in the genuine spirit of collaboration
• Core commitment to safety, integrity, compliance, quality, and service
Team Lead - Synthetic Chemistry
Strategic Responsibilities
Safety :
• Commitment to safety (self, team, lab and the organization) always
• Ensuring ZERO safety incidents in the lab/organization
• Ensuring ZERO safety non-compliances at workplace.
• Reporting incidents (or near-misses) and learnings from those incidents to avoid recurrence
• Near miss reporting 1 per year per employee, Reduction in number of first aid injuries reported compared to previous FY, Review SOPs and checklists for completeness of information related to safety
Quality :
• Ensure to comply with Syngene’ s quality standards and services (self and team) always
• ZERO data integrity incidents
• Adhere to the ALCOA+ principles in all data generated. Ensuring adherence to all Syngene policies related to data integrity by all team members.
• Maintain confidentiality
• Zero repeat audit observations, Zero major and critical observations in external audits, SOP’s vs Practices:
• Review and implement necessary refinements for continuous training, testing, and tracking SOP compliance
• Deviations <= 2% within the fiscal year, tracked monthly
Delivery
• Responsible for Project Health Index: Project planning, Execution, Deliverables including tracking of KPIs for his/her team and Quality of services (internal/client metrics)
• Achieve per-quarter improvement in key FY25 KPIs, per OU per plan, 18-20 steps per FTE per month, 6 compounds/FTE/month, 70% targets TAT within 30 days for deliverables <0.1 g scale and 5 CE/FTE/month for scales >0.1 g scale.
• Help the Group Leaders and Head of the department in managing the process of governance & tools for effective, transparent, and collaborative management of the projects.
Engagement :
• Good in engaging the customers (weekly reports, experimental for completed final compounds etc). Zero flaw in presentations and report, real time and flawless communication
• 0% business attrition w.r.t scientific environment and work culture
• Support in implementing comprehensive client feedback collection and response platform in collaboration with PMO as service management piece. Demonstrate consistent, sustainable technical and operational improvements per RCA/CAPA process in Synthetic chemistry
• Excellent in team and cross-functional engagement
Cost :] • Manage lifecycle of various lab infrastructure, instruments.
• Ensure optimum resource utilization and cost efficiencyManage FH to chemist ratio.
• Maintain above 50 % of Scientist-1 in the team and around 25 % of Scientist-2 employees.
Compliance :
• Adhere to the ALCOA+ principles in all the experiments and data generated. Ensuring adherence to Syngene policies related to data integrity by all team members.
• ALCOA+ deviations <= 2% within the fiscal year, tracked monthly, zero data integrity incidents: Breaches that would lead to a material breach with client or regulator
• Gemba walk compliance at 100%, Timesheet compliance at 100%
• Confidentiality compliance
• Ensuring all assigned mandatory training related to data integrity, health, and safety measures are completed on time by all team members.
People :
• Leadership Next and Succession planning for critical roles – Reduce critical talent attrition by <5%, create succession plans for critical roles
• Build competencies and skills that are required to achieve current and future business needs.
Walk in Interview
Date and Time for Registration : 15th Dec 2024, 9:00AM to 12:00PM
Venue : Syngene Scientific Solution Ltd., Knowledge | Square Park -9000, Plot No.7, Survey No.542, MN Park, Synergy Square 2 Genome Valley, Kolthur Shamirpet, Medchal, Hyderabad, M Telangana 500078
Medicinal Chemistry Scientist : Click here
Team / Project Lead : Click here
Team Lead - Synthetic Chemistry : Click here
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