The Biocon Bristol Myers Squibb Research & Development Center (BBRC) in Bangalore is an expansive R&D facility established through a collaboration between Bristol Myers Squibb and Syngene International, a Biocon group company.
Post : Immuno - Oncology Scientist Translational Medicine
Seeking a motivated PhD level scientist to join the Translational Medicine team at the Biocon Bristol Myers Squibb Research Center in Bangalore, India. Key responsibilities of this role are to serve as a scientific lead and coordinator for the preclinical support of asset programs through mechanism of action-based studies, differentiation from standard of care and competitive therapeutics, combination rationale, new indications (life cycle management), and patient selection strategies. S/He will work directly with translational scientists, disease leaders within translational medicine, and will also interact with thematic research centers in early development within the company. In addition, guidance of laboratory scientists to generate data in support of clinical development decisions will be required.
Job Description
• The candidate must possess a thorough understanding of relevant disease biology, the clinical landscape, emerging technologies, and the competitive environment.
• The candidate should demonstrate exceptional laboratory technical skills in cell and molecular biology, and/or in vivo pharmacology and proficient at devising strategic solutions to identify and resolve potential challenges.
• Capable to design, guide and conduct experiments (both in vitro and in vivo) to generate data supporting novel MOA, rational combination strategies, dosing strategies, and resistance mechanisms for early and late stage clinical assets.
• Exceptional scientific managerial skills are crucial for effective interaction with cross-functional teams, ensuring the delivery and reporting of scientific outcomes.
Key Responsibilities
• Conduct preclinical/laboratory experiments on late stage BMS portfolio compounds to support annual goals and objectives for Translational Medicine (for internal /external, collaborations, compound specific plans etc).
• Responsible for delivering data in support of translational strategies including biomarkers, patient selection hypotheses, dose and schedule, combination strategies, resistance mechanisms and differentiation. • Report directly to the head of the laboratory and manage laboratory scientists to integrate clinical questions into lab-based translational research internally and externally.
• Interfaces with TM scientists to ensure seamless flow of information for assets which are entering the remit of translational medicine.
• Manages and supervises a portfolio of preclinical collaborations on specific pipeline compounds or clinical assets.
• Assists in managing key strategic and/or collaborative projects along with TM scientists.
• Communicates regularly and prepares and makes presentations within the department, externally and to senior management as required.
• Reports experimental finding in written nonclinical pharmacology study reports, to support regulatory filings.
• Assists in setup and maintenance of group budget and personnel plan
Candidate Profile
• PhD with relevant work experience across immunology, oncology, heme-oncology focus areas including drug development in an industry setting, especially hematology indications is a plus.
Technical Skills
• Strong publication record and track record in large and/or small companies, leading innovative efforts within the laboratory setting to achieve defined goals and support clinical development
• Excellent communication, managerial and scientific qualities are expected
• Ability to interact effectively across boundaries using influencing and relationship building skills.
• Competence in analysis and solving of problems, and the ability to prioritize and make tradeoffs to achieve goals.
• Understanding of relevant disease biology, clinical landscape, evolving technologies, competitive scenario
• Cell culture, primary cell isolation, cell transfection
• Proficiency in gene expression methods including qRT-PCR and/or familiarity with RNA sequencing, epigenomic methods including ATAC-seq ChiP-seq,
• Protein analyses and immunoassays, and cell phenotyping analysis
• Familiarity with design, setup and execution of autoimmune, solid tumor oncology or heme-oncology in vivo pharmacology models is a plus.
• Obtain relevant information from published literature, both internal and external. Apply information gathered to solve complex scientific questions and help study data interpretation.
• Maintain a good understanding of the methodological basis and biological significance of assays performed.
• Forecast potential issues regarding support of assays for current and long term projects.
• Devise strategic solutions to identified and potential hurdles/issues; efficiently and proactively troubleshoot technical and experimental problems.
Additional Information
Experience : 3 to 5 years
Qualification : Ph.D
Location : Bangalore
Industry Type : Pharma/ Healthcare/ Clinical research
End Date : 25th December 2024
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