Across the globe, Lilly employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to communities through philanthropy and volunteerism. We were founded in 1876 by Colonel Eli Lilly, a man committed to creating high-quality medicines that meet real needs. More than a century later, we are passionate about building on this precedent in our continued pursuit to make life better for individuals, communities, and the world around us.
Post: Senior Research Scientist-ADME
Job Description:
The Biotechnology Research/ADME group is responsible for evaluating the preclinical pharmacokinetics and disposition of therapeutic proteins/peptides and monoclonal antibodies. The team interfaces with toxicology, discovery biology, protein engineering and multiple therapeutic areas to help identify and characterize optimal therapeutic candidates to advance to clinical testing. The group is expanding capabilities in analytical, cell biology and PK/PD to more fully characterize factors influencing the absorption and disposition of biologic therapeutics.
Position Brand Description:
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Develop/validate cell based methods/systems to study mechanisms of cellular uptake and degradation of therapeutic monoclonal antibodies
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Develop and refine in vitro systems to study and optimize antibody transport into the central nervous system
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Develop cell based models to study antibody-receptor trafficking patterns and interactions with FcRn
- Participate in cross-functional working groups
Key Objectives/Deliverables:
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Development/characterization of novel cell based assay systems
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Interface with biology, discovery research and protein engineering groups
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Write preclinical study reports
Candidate Profile:
PhD degree in cell biology, biochemistry, immunology
Minimum of 3 years of experience studying cellular mechanisms of antibody disposition
Additional Skills/Preferences
Experience in the development/validation of cell based assays
Experience with flow cytometry, confocal microscopy and high content imaging
Experience with immunoassay formats and applications development
Experience with antibody labeling methods, protein fractionation, chromatography handling of radioisotopes
Experience with immunohistochemical techniques
Strong written and verbal communication skills
Additional Information: Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
State / Province: Indianapolis - USA
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