The group of Biomedical and Metabolomic Analysis (BMA) and the Molecular Pharmacology group of the University of Geneva are seeking a dynamic, highly motivated and talented PhD student to join their research teams. The Biomedical and Metabolomics Analysis group develops cutting-edge analytical methods for monitoring small exogenous and endogenous molecules in complex biological matrices, with a strong focus on metabolomics. The Molecular Pharmacology group develops optimized synergistic multidrug mixtures to improve cancer therapy.
Vacant position : PhD
Project description
A PhD position is currently available for a research endeavor funded by the Swiss Centre for Applied Human Toxicology. The goal of this PhD project is to investigate the toxicological effects of drug combination therapies on the metabolic pathways in different tumor types and cell models. For this purpose, the PhD student will learn and apply both cell culture techniques and metabolomic approaches to understand how cells adapt their metabolism when exposed to different toxicant combinations at low doses. The PhD candidate will thus be working closely at the interface between two leading groups in these areas: the Molecular Pharmacology group, where the cancer models are established and the BMA group, which routinely runs metabolomics workflows. We offer an ambitious multidisciplinary project that will allow the candidate to be in contact with various aspects of toxicology research, mainly cell cultures and liquid chromatography hyphenated to mass spectrometry (LC-MS), as well as data analysis and bioinformatics (i.e. compound annotation and pathway analysis using databases and online tools). He/she will become part of a large network of leading researchers and professionals committed to innovation and excellence in toxicological and biomedical research in Switzerland. The project is highly transversal and will require competences in biology, toxicology, analytical chemistry and data handling. The candidates will also actively participate in dissemination activities concerning the outcomes of their research (meetings with research partners, preparation of papers, presentation of results on a regular basis in national and international conferences).
Profile
The successful candidate must have a Master degree in pharmaceutical sciences, biochemistry, chemistry, or related disciplines with a strong background in biology. Due to the interdisciplinary nature of the project, the applicants should have a strong ability to work as a part of a team and collaborate with various partners. Basic knowledge in LC-MS, and data handling is highly desirable. The candidates should have excellent communication and writing skills in English. Being able to teach in French will be considered as a plus. The position is funded for 4 years. The PhD student will have a position of part-time assistant. He/she will participate to teaching activities for undergraduate students. The salary will follow the School of Pharmaceutical Sciences standards. Review of applications will begin immediately and continue until the position is filled.
Location : University of Geneva, Centre Médical Universitaire
Starting date / duration : September 1st 2023 / 4 years
Please send your application including a complete CV, short motivation letter and the names and contacts of at least 2 references directly to Prof. Serge Rudaz (serge.rudaz@unige.ch) and/or Prof. Patrycja Nowak-Sliwinska (Patrycja.nowak-sliwinska@unige.ch)
Application deadline : 30 April 2023
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