Centre for Chemical Biology and Therapeutics invites Senior Scientist, HTC Technology Associate, Associate Research Scientist, Research Associate, Computational Biologist

Applications are invited from qualified, creative, self-motivated scientists for several positions in The Centre for Chemical Biology and Therapeutics (CCBT). The successful candidate will participate in a multidisciplinary research program in a new initiative for chemical biology and therapeutics research. The program is coordinated by Professor Ashok Venkitaraman (University of Cambridge, UK, and inStem)

Name of the post and qualification/experience for each one are indicated below -

Post: Senior Scientist, HTC Technology Associate, Associate Research Scientist, Research Associate, Computational Biologist

SENIOR SCIENTIST – HTS AUTOMATION BIOLOGIST
KNOWLEDGE, EXPERIENCE AND SKILLS:

• PhD in Molecular Biology/Cell Biology/Biochemistry
  
• 2-4 yrs of experience in assay design, execution and screening
  
• Previous experience in using liquid handling stations, implementing high content screens, automated microscopy and managing large data sets are encouraged to apply
  

JOB DESCRIPTION

• In this position you will support chemical biology efforts underpinning new lead discovery by providing high throughput biology expertise including, but not limited to the following;
  
• Develop, optimize and validate biological assays amenable to automation and high throughput screening
  
• Automate high throughput screening assays to support lead discovery programs
  
• Perform primary high throughput screening, secondary hit profiling assays, and focused small molecule screens
  
• Program and operate custom-integrated automation systems, prepare assay reagents and execute assays
  
• Perform data analysis, reporting and integration with database software
  
• Interact with multidisciplinary project teams for lead discovery
  
• Participate in project team meeting and contribute to the projects intellectually and communicate data
  

ESSENTIAL DUTIES AND JOB FUNCTIONS

• Specific experience with high throughput screening and assay development
  
• Experience in biochemical and cell based assays applying luminescence, fluorescence, TR-FRET, FP, alpha screen, fluorescent immunocytochemistry, high content analysis, automated microscopy, label-free and other in vitro detection technologies
  
• Solid understanding of modern high throughput screening assay technologies
  
• Specific experience using laboratory automation equipment
  
• Excellent computer skills with experience in data analysis
  
• Must be detail oriented, well organized, and have strong communication skills
  
• Excellent teamwork skills and the ability to work in a fast-paced, multi-disciplinary environment and managerial experience of junior scientists
  

HTS TECHNOLOGY ASSOCIATE
KNOWLEDGE, EXPERIENCE AND SKILLS:
Master's degree in discipline of life sciences with 1-3 years of work experience
Substantial experience in high throughput screening through enzyme/cell-based assays using small molecule libraries is essential
JOB DESCRIPTION
In this position you will support chemical biology efforts underpinning new lead discovery efforts by providing high throughput biology expertise including, but not limited to the following;

• Proficient in biochemistry, enzymology, assay development, lab automation and HTS
  
• High throughput screening assays and application of various in vitro techniques
  
• Specific experience with biochemical and cell based assays applying luminescence, fluorescence, TR-FRET, FP and alpha screen assays
  
• HTS sample processing, data generation, data interpretation and data reporting
  
• Assist in maintenance of HTS compound/sample libraries, laboratory administrative requirements and maintenance of good laboratory practices in work environment
  

ESSENTIAL DUTIES AND JOB FUNCTIONS

• Understanding of modern high throughput screening assay technologies
  
• Experience in using laboratory automation equipment
  
• Computer skills with extensive experience in data management, data analysis and statistical analysis
  
• Must be detail oriented, well organized, and have strong communication skills
  
• Excellent teamwork skills and the ability to work in a fast-paced, multi-disciplinary environment
  

SENIOR SCIENTIST –Cell Molecular Biologist/Assay Development
KNOWLEDGE, EXPERIENCE AND SKILLS:

• PhD in Molecular Biology/Cell Biology/Biochemistry or other relevant fields
  
• 2-4 yrs of postdoctoral/industry experience in cell-based assay development, immunocytochemistry/high-content imaging
  
• Experience in basic biochemistry techniques like immunoprecipitations, pull down assays, Western blotting etc. is required
  
• Knowledge in basic Molecular biology techniques like transformations, cloning, site-directed mutagenesis and stable cell line generation would be desirable
  
• Self-motivated candidates who can drive research projects and should manage junior scientists with the capability to design, develop and troubleshoot experiments
  
• Excellent communication and presentation skills
  
• Must be detail oriented, organized with ability to analyze and communicate data effectively
  
• Excellent teamwork required and to work in a fast-paced, multi-disciplinary environment, meeting timelines
  
• Good understanding of cell signaling pathways, disease biology having therapeutic implications would be required
  

JOB DESCRIPTION

• In this position you will support chemical biology efforts underpinning new lead discovery by providing cell biology expertise including, but not limited to the following;
  
• Develop, optimize and validate cell-based assay platforms for the hit to lead identification of small molecules in our drug discovery programs
  
• Collaborate with project teams like high throughput screening, computational biology, medicinal chemistry and protein biology to develop lead molecules
  
• Plan experiments, order reagents, set up assay platforms and deliver data in a timely fashion
  
• Regular data analysis, project updates, literature survey and presentations
  
• Participate in project team meeting and contribute to the projects intellectually
  

DUTIES AND JOB FUNCTIONS

• Specific experience with cell biology and assay development using luminescence, fluorescence, TR-FRET, FP, fluorescent immunocytochemistry, high content analysis, automated microscopy, label-free and other in vitro detection technologies
  
• Ability to work on the bench implementing state-of-the-art technologies for the different assay platforms
  
• Capability to perform basic biochemistry and molecular biology techniques
  
• Excellent in data analysis, interpretation and communication
  
• Must be detail oriented, well organized, and have strong communication skills
  
• Excellent teamwork skills and the ability to work in a fast-paced, multi-disciplinary environment
  
• Managerial experience of junior scientists
  

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ASSOCIATE RESEARCH SCIENTIST: Cell Molecular Biologist/Assay Development
KNOWLEDGE, EXPERIENCE AND SKILLS:

• Master's degree in the discipline of life sciences with 1-3 years of academic or industrial work experience
  
• Substantial experience in cell based assay development, immunocytochemistry, biochemistry (immunoprecipitations, Western blotting etc.) and molecular biology techniques (transformation cloning, stable cell line generation etc.) would be preferred
  
• Must be detail oriented, well organized with ability to analyze and communicate data effectively
  
• Excellent teamwork required and to work in a fast-paced, multi-disciplinary environment meeting timelines
  

JOB DESCRIPTION

• In this position you will support chemical biology efforts underpinning new lead discovery by providing cell biology expertise including, but not limited to the following;
  
• Develop, optimize and validate cell-based assay platforms for the hit to lead identification of small molecules in our drug discovery programs
  
• Collaborate with multidisciplinary project teams like high throughput screening, computational biology, medicinal chemistry and protein biology in the discovery and identification of small molecules
  
• Plan experiments, order reagents and set up assay platforms and deliver them in a timely fashion
  
• Regular data analysis, project updates, literature survey and presentations on the target
  
• Participate in project team meeting and contribute to the projects intellectually
  

DUTIES AND JOB FUNCTIONS

• Understanding of cell biology, molecular biology and assay technologies
  
• Experience in using luminescence, fluorescence, TR-FRET, FP, fluorescent immunocytochemistry, high content analysis, automated microscopy, label-free and other in vitro detection technologies
  
• Computer skills with experience in data analysis
  
• Must be detail oriented, well organized, and have strong communication skills
  
• Excellent teamwork skills and the ability to work in a fast-paced, multi-disciplinary environment
  

SENIOR SCIENTIST- Computational chemistry
KNOWLEDGE, EXPERIENCE AND SKILLS:

• PhD in chemistry or computational chemistry or other relevant fields.
  
• 2-4 yrs of postdoctoral/industry experience in the application of computational tools to facilitate the design and optimization of potent and selective small molecules against various targets.
  
• Competence with structure-based and ligand-based design techniques like protein modelling, virtual screening, QSAR, molecular dynamics simulations with strong programming/scripting in Perl, python and R is required.
  
• Experience in applying modelling packages such as CCG, Schrödinger, CCDC, OpenEye or Accelrys is required
  
• Knowledge in data analysis and data pipelining tools like Knime is desirable.
  
• Background in organic/medicinal chemistry with understanding of chemical building blocks and common linkers used in medicinal chemistry is essential
  
• Must be detail oriented, well organized with ability to analyze and communicate data effectively
  
• Excellent teamwork is required to work in a fast-paced, multi-disciplinary environment
  

JOB DESCRIPTION
In this position you will drive lead discovery projects by proposing testable hypothesis using computational chemistry tools. You will have to perform the following

• Tailor small molecule modelling strategies based on the available experimental data and direct assays to test predictions
  
• Perform cheminformatics analysis, calculate molecular properties, cluster and perform varied similarity searches
  
• Understand the effect of mutations in the pocket, determine selectivity determinants among closely related protein family members
  
• Employ ligand-based and structure-based approaches for iterative improvement of compound potency and selectivity
  
• Play a major role in lead identification, optimization, scaffold hopping and fragment linking
  

DUTIES AND JOB FUNCTIONS
Perform statistical analysis of screening results and build QSAR models.
Determine the binding mode of hits by generating interaction fingerprints, performing pharmacophore guided molecular docking and MD simulations.
Propose modifications that can exploit the unexplored interactions in pocket to improve potency and selectivity.
Propose new leads by virtual screening, scaffold hopping, fragment linking, ligand/pocket similarity searches, etc.
Present a rational and testable hypothesis

RESEARCH ASSOCIATE - Computational chemistry
KNOWLEDGE, EXPERIENCE AND SKILLS:

• Master's degree in the discipline of chemistry/pharmacology with 1-3 years of academic or industrial work experience in the application of computer-aided drug discovery tools in proposing practical hypotheses.
  
• Competence with structure-based and ligand-based design techniques like protein modelling, virtual screening, QSAR, molecular dynamics simulations with strong programming/scripting in Perl, python and R is required.
  
• Must be motivated, well organized with the ability to analyze and communicate data effectively
  
• Excellent teamwork is required to work in a fast-paced, multi-disciplinary environment
  

JOB DESCRIPTION

• In this position you will drive lead discovery projects by proposing testable hypothesis using computational chemistry expertise.
  
• Generate chemical databases, develop conformations, calculate molecular properties, cluster and perform varied similarity searches
  
• Employ ligand-based and structure-based approaches for iterative improvement of compound potency and selectivity
  
• Regular data analysis, project updates, literature survey and presentations on the target
  
• Participate in project team meeting and contribute to the projects intellectually
  

DUTIES AND JOB FUNCTIONS

• Generate chemical libraries, perform statistical analysis of screening results and build QSAR models.
  
• Determine the binding mode of hits by, performing pharmacophore guided molecular docking and MD simulations.
  
• Propose modifications that can exploit the unexplored interactions in pocket to improve potency and selectivity.
  
• Apply virtual screening, scaffold hopping, fragment linking, ligand/pocket similarity searches, etc.
  
• Present a rational and testable hypothesis
  

COMPUTATIONAL BIOLOGIST
KNOWLEDGE, EXPERIENCE AND SKILLS:

• Master's/Bachelor’s degree in computer science, computational biology, bioinformatics or related area and at least 1-2 years of professional programming experience.
  
• Broad array of technical skills such as the knowledge of databases and search engines, statistical analysis tools and environments, visualization tools, and the ability to quickly create research-grade programs and scripts.
  
• Experience performing statistical analysis on large data sets, including proficiency in programs such as R and Matlab
  
• Experience in developing bioinformatics applications using programming languages like Java, Python and Perl; knowledge of SQL and relational databases like Oracle, MySQL, SQL Server
  
• Ability to administer and manage various operating systems like MacOSX, Windows and Linux
  
• Experience using Apache, HTML, CSS, CGI, BioPerl, BioPython
  

JOB DESCRIPTION
In this position you will support drug discovery effort by providing computational biology expertise including but no limited to the following;

• Monitoring project status, identifying and resolving problems which may impact the project results
  
• Maintaining research software and hardware
  
• Develop and implement data management policies
  
• Scientific application alternatives, security, software usage, capacity planning, training, data recovery and backup procedures
  
• Individual should be able to seamlessly interface biology with computational skills and develop new tools and methods
  

Essential Duties and Job Functions

• Provide centralized in-house facilities for bioinformatics requirement of CCBT in liaison with central IT department at NCBS.
  
• Management of databases, Laboratory Information Management System (LIMS), scientific software,
  
• Augmentation of software and scientific tools used in drug discovery processes
  
• Computer skills with experience in data analysis including statistical analysis
  
• Must be detail oriented, well organized, and have strong communication skills?
  
• Excellent teamwork skills and the ability to work in a fast-paced, multi-disciplinary environment?
  

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SENIOR SCIENTIST: STRUCTURAL BIOLOGY
KNOWLEDGE, EXPERIENCE AND SKILLS:

• PhD in Structural Biology or Biochemistry or other relevant fields.
  
• 2-4 yrs of postdoctoral/industry experience in the application of structural biology/protein chemistry set up
  
• Hands on experience in cloning, recombinant protein expression and purification
  
• Expertise in solving protein structure by crystallization, X-ray diffraction and related tools.
  
• Working knowledge of instruments such as protein fermenter, FPLC, circular dichroism, isothermal calorimetry, dynamic light scattering, Surface Plasmon resonance etc
  
• Must be detail oriented, well organized with ability to analyze and communicate data effectively
  
• Excellent teamwork is required to work in a fast-paced, multi-disciplinary environment
  

JOB DESCRIPTION

• In this position you will coordinate with cell biologists, computational and medicinal chemists to understand the molecular nature of the protein-ligand and protein-drug interaction.
  
• Oversee and coordinate cloning, protein expression and purification
  
• Coordinate cross-departmental activities for the effective use of purified proteins
  
• Biophysical characterization of protein-ligand and protein-small molecule interaction
  
• Support and enable reproducible large-scale protein purifications in quantity and quality suitable for X-ray crystallography
  
• Regular data analysis, project updates, literature survey and presentations on the target
  
• Participate in project team meeting and contribute to the projects intellectually
  

DUTIES AND JOB FUNCTIONS
The successful candidates will work in the area of protein science and structural biology, which include design, express, and purify proteins, and elucidate protein-protein interactions. Primary responsibilities include:

• Support protein design, expression and purification to support small-molecule discovery
  
• Biophysical characterization of proteins and protein-ligand complexes to facilitate protein crystallization and protein science studies (e.g. ITC, AUC, DSC, fluorescence)
  
• Design of protein constructs for SBDD and protein sciences experiments
  
• Integrating structural biology expertise into cross-functional project teams?
  
• Lead determination of high quality protein structures and co-crystal structures through crystallization, data collection and refinement
  
• Communicating effectively with medicinal and computational chemists to translate hit to leads
  

HOW TO APPLY: Interested candidates may send in the following information by email to jobs-ccbt@instem.res.in.

Curriculum Vitae (CV)
Publication list
Contact details of three professional referees.

NO PAPER APPLICATIONS will be accepted.

The Centre for Chemical Biology and Therapeutics (CCBT) is an inter-institutional collaboration funded by the Department of Biotechnology, Government of India, the Institute for Stem Cell Biology and Regenerative Medicine (inStem) and the University of Cambridge (instem.res.in/research/research-themes/center-for-chemical-biology-and-therapeutics). It is an integrated multidisciplinary research centre designed to pioneer new approaches to create small-molecule tools that target intracellular signaling pathways for chemical biology and molecular therapeutics, and use them to conduct hypothesis-generating and hypothesis-driven translational research on systems of biomedical importance. Its overall vision will be to foster innovative therapeutic interventions for important human diseases. It is located on the NCBS campus (ncbs.res.in) in north Bangalore, a premier site for biomedical research equipped with the latest instrumentation and facilities, with a flourishing community of academic and industrial researchers. The CCBT operates through the uniquely integrated effort of multidisciplinary project teams using common technological platforms, and not as a collection of independent PI-led labs that is usual in academia.

The prescribed qualification/experience for Senior Scientists is Ph.D. with 2-4 years of Post-doctoral experience in the relevant area and for Associates it is Master’s/Bachelor’s degree with 1-3 years experience of Academic or Industrial work experience.

Age will not be bar for candidates with exceptional experience in the specific field. Outstanding young Ph.D.s are also encouraged to apply for Senior Scientist positions.

Salary and benefits will be attractive and will be commensurate with qualification/experience and performance in the interview.

Appointments to these posts are made for one year and extended thereafter based on performance of the candidate during the course of the CCBT project.

Applications received upto 29^th April 2014 will be considered in the first lot and thereafter reviewed periodically and screening/ selection taken up as appropriate.

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