Articles

ABOUT AUTHORS:
Tara Shankar Basuri^1*, Ishvar Parmar¹, Vishal Modi², Virag Shah³, Niyatee Thakur⁴
SSR College of pharmacy, Silvassa,
U.T of Dadra & Nagar Haveli-396230
*tbasuri@gmail.com

ABSTRACT
Malignant melanoma is the most lethal form of skin cancer and an increasingly common disease worldwide. It remains one of the most treatment-refractory malignancies. The current treatment options for patients with metastatic melanoma are limited and in most cases non-curative. This review focuses on novel synthetic and herbal drugs for malignant melanoma treatment, by a single or combinational agent approach. These molecules are widely used by the oncologists for the treatment of this type of cancer. So this review can help to the public to aware the malignant melanoma and its treatment and novel target for its treatment.

About Author:
Banwari Lal Gupta
L.R.S. Institute of Tuberculosis & Respiratory Diseases,
New Delhi-110030
banwarigupta141@gmail.com

Abstract
Despite decades of research and drug development for cancer treatment, cancer still remains one of the major causes of human death in the world. An important aspect in cancer therapy is the development of a targeted drug delivery system that decreases the toxic side effects of chemotherapy and other cancer therapies. The current conventional method in treating cancer involves inserting catheters to allow for chemotherapy, to reduce the amount of cancer present, and/or then to surgically remove the tumors, followed by more chemotherapy and radiation sessions.
Research on thermal therapy- the heating of pathological tissue using energy source (radiofrequency, microwave, high-intensity focused ultrasound or laser energy and cryosurgery. There are clear reasons for using hyperthermia in cancer treatment. Treatment at temperatures between 40-44°C is cytotoxic for cells in low pO2 and low pH environmental conditions, which are found specifically within the tumor tissue, due to insufficient blood perfusion. Under such conditions radiotherapy is less effective, and systematically applied cytotoxic agents will reach such area in lower concentrations then in well perfused area. Therefore the addition of hyperthermia to chemotherapy or radiotherapy will result in at least an additive effect. Furthermore, the effects of both radiotherapy and many drugs are enhanced at an increased temperature. Hyperthermia can be allied by several methods such as: local hyperthermia, regional hyperthermia, and whole-body hyperthermia.
Countless researches are on their way, in the relation of improvement of heating techniques, development of hyperthermia planning models and thermometry. The clinical studies have confirmed future expectations of hyperthermiawould be valuable. Hyperthermia is a potential combined approach and deserving more attention for its further development. This article will throw the lights on hyperthermia therapy for improvement of cancer treatment.

ABOUT AUTHORS:
Madhuri D. Ghadage*¹, Gajanan H. Banapure^2
1Department of Pharmaceutics, SMBT College of Pharmacy, Dhamangaon, Nashik
²H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur Dhule
*maadhuri.ghadge@gmail.com

ABSTRACT
The controlled release of drugs in slow and sustained manner is one of the major challenges in drug delivery system. Targeting of drug to the particular site is an important aspect of drug delivery system. Carrier technology offers an intelligent approach for drug delivery by coupling the drug to a carrier particle such as microsphere which modulates the release and absorption characteristics of the drug. These delivery systems offer numerous advantages over the conventional dosage forms including improved efficacy, reduced toxicity, and improved patient compliance. Microspheres received much attention not only for prolonged release, but also for targeting of anticancer drugs. In future microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, genetic materials, targeted and effective drug delivery. The current aim of this review is to study various aspects of the microparticulates drug delivery system including method of formulation, evaluation & characterization.

ABOUT AUTHOR:
Amitava Sinha Ray
Department of Pharmacy,
Bengal School of Technology
West Bengal University of Technology, West Bengal
a.amitava.s@gmail.com