July 2017 ARTICLE LIST >>
PharmaTutor (July - 2017)
ISSN: 2347 - 7881
(Volume 5, Issue 7)
Received On: 04/04/2017; Accepted On: 04/04/2017; Published On: 01/07/2017
AUTHORS:
R.Natarajan*, Abirami.M, , Pavankumar.J, and G.Murugananthan
Department of Pharmaceutics & research
Swamy Vivekanandha College of pharmacy,
Elayampalayam, Namakkal, Tamilnadu, India
*svcpnatarajan@gmail.com
ABSTRACT:
The work was carried out to formulate and evaluate the matrix transdermal patches of Lamivudine for the controlled delivery of drug in the body. The transdermal patches were prepared by the solvent casting method using Span-80 as a permeation enhancer and were prepared in different drug: polymer (Lamivudine: HPMC and Lamivudine: EC) ratios of 1:2.5, 1:5, without permeation enhancers and with permeation enhancers. The prepared transdermal patch were found to be good physicochemical properties, shows no skin irritation on the rat skin and subjected to in vitro drug permeation study by using rat skin in phosphate buffer pH 7.4 for 24 hours. The comparative statistical analytical data (ANOVA) showed ‘p’ value < 0.0001 which suggest that the prepared formulation are extremely significant for transdermal delivery. The formulation (FPE2) ratio 1:5 of (Lamivudine: HPMC) patch with permeation enhancer showed best result among all the formulation. This formulation (FPE2) was subjected to in-vivo studies by using rat. The in-vivo studies of the patches were administrated transdermally to rat skin and while a standard solution of 10μg/ml was used as a control, and collected the plasma drug sample at different time interval and analyzed by HPLC. The in-vitro in-vivo correlation studies shows the regression value (R) 0.863 and correlated and to be linear.
How to cite this article: Natarajan R, Abirami M, , Pavankumar J, Murugananthan G;A novel transdermal patch of Lamivudine: Invitro-Invivo characterization; PharmaTutor; 2017; 5(7); 54-62
[ABSTRACT WITH CITATION] [VIEW AS HTML]
REFERENCES:
1. Ratan Mehta. “Topical and transdermal drug delivery”: What a Pharmacist need to know. ACEP; 1-10.
2. Joint united nations programme on HIV/AIDS (ON AIDS) and WHO” AIDS epidemic update 2005”, Geneva https://www.Unaids.org.
3. Roopa pai S. and Kusum Devi V. “Lamivudine liposomes for transdermal delivery formulation, Characterization, Stability and Invitro Evaluation”. International journal of pharmaceutical sciences and nanotechnology Volume 1. Issue 4. January – March 2009 p317-326.
4. Gupta Ritu, Bajpai Meenakshi, Bhattaracharya Arundhati. “Formulation and invitro evaluation of transdermal drug delivery system of Tizanidine hydrochloride” Journal of pharmaceutical research.2008;7(4):p208-213.
5. G.S. Sanap,G.Y.Dama, “Preparation of transdermal monolithic systems of indapamide by solvent casting method and the use of vegetable oils as permeation enhancer” International journal of green pharmacy, April – June,2008,p129- 133.
6. Rathore RPS, Chauhan C S, Naruka P S, Tanwar Y S and Chauhan L S. “Transdermal formulation of Terbutaline sulphate”. Pharmacy On-Line, April 2006. www.priory.com.
7. Yuveraj Singh Tanwar, Chetan Singh Chauhn, Anshu Sharma. “Development and Evaluation of Carvedilol Transdermal patches”. Acta Pharm. 57(2007)p151-59.
8. Janardhanan Bagyalakshmi, Ramachandra Purapu Vamsikrishna, Rajappan Manavalan, Thengungal Kochupappy Ravi and Probal Kumar Manna. “Formulation Development and in vitro and in vivo Evaluation of Membrane Moderated Transdermal Systems of Ampicillin Sodium in Ethanol: ph 4.7 Buffer Solvent System”. AAPS PharmSciTech.2007; 8 (1) Article 7. https://www.aapspharmscitech.org.
9. Jianping Wang, Jinlan Ruan,Changgog Zhang, Yujie Ye, Yaling Cai and Yanxia Wu. “Development and Evaluation of the Sinomenin Transdermal patch”. Pak. J. Pharm. Sci., Vol.21, No.4, October 2008,p407-410.
10. V kasum Devi, S saisivam G R maria “Design and evaluation of matrix controlled transdermal patch of verpamil Hcl” Drug development and industrial pharmacy 2003.vol-29 NO5 page-503.
11. Talasila Eswara Gopala Krishna Murthy, Vankayalapati Sai Kishore. Efect of Casting solvent and polymer on permeability of propranol hydrochloride through membrane-controlled transdermal drug delivery system”. Asian Journal of Pharmaceutics - April- June 2008.p86-90.
12. Kulkarni Raghavendra, H. Doddayya, Dr.S.C. Marihal, C.C.Patil, and P.V. Habbu. “Comparitive Evaluation of Polymeric Films for Transdermal Application”. The Eastern Pharmacist.2000; 43;p109-111.
13. G. Ramesh, Vamshi Vishnu Y, Kishan V and Madhusudan Rao Y. “Studies on the influence of penetration enhancers on in vitro permeation of carvedilol across rat abdominal skin”. Current Trends in Biotehnology and Pharmacy, Vol.1 (1)p62-69(2007).
14. Dr. Shyam S. Agrawal , Dr. Manoj P. Jadhav.“In-vitro, in-vivo, transdermal permeation of Carvedilol from Chitosan based matrix-type transdermal patches” AAPS National Biotechnology Conference , 2006.
15. Roop K Khar, S P Vyas, “Controlled drug delivery concept and advances” Ist Edition , 2002 Page No-442-443.
16. Mohamed aqili, Yasmis sultana, Asgar Ali, “Matrix type transdermal drug delivery system of Metaprolol tatarate: In vitro characterization” Acta pharm, 53 (2003).p 120.
17. Gupta Ritu, Bajpai Meenakshi, Bhattacharya Arundhati, “Formulation and In-vitro evaluation of Transdermal drug delivery system of Tizanidine Hydrochloride”, Journal of Pharmaceutical Research, Volume:7, No:4, October 2008, Page:208 to 213.
18. Faiyaz Shakeel, Sanjula Baoota, Alka Ahuja, Javed Ali, Mohammed Aqil and Sheikh Shafiq. “Nanoemulions a vehicles for Transdermal Delivery of Aceclofenac”. AAPS PharmSciTech.2007; 8 (4) Article 104. https://www.aapspharmscitech.org.
19. Srinivas Mutalik, nyanabhirama Udapa, “Formulation, Development ,invitro and invivo evaluation of membrane controlled transdermal system system of Glibenclamide”, J Pharm Pharmaceutical Sci, 2005;8(1): p26-38.
20. Chanshun Ren, Liang Fang, “Design and in vivo evaluation of an Indapamide transdermal patch”, International Journal of Pharmaceutics, 2009;p129-135.
21. Mr.C.Kumaresan, “In -Vitro In -Vivo Studies in Pharmaceutical Development, pharmainfo.net” , vol 6, Issue 2, 2008.
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