March 2015

Department of Pharmacy, Tripura University provides an excellent opportunity for young and motivated researchers to pursue a career in pharmaceutical chemistry and medicinal chemistry research. Department of Pharmacy endeavors in providing better human health through innovative research. The labs are equipped with state-of-the-art facilities to conduct animal and in-vitro experimentation with an interdisciplinary approach.

A. R. College of Pharmacy & G. H. Patel Institute of Pharmacy (ARGH) is one of the best Pharmacy Institutes in the Gujarat region. CVM set up an institute offering D. Pharmacy in the year 1981, with generous donation from eminent philanthropist Shri Gordhanbhai Hathibhai Patel & in the very next year i.e 1982 established with donation from an industrialist Smt. Anjanaben Ashokbhai Shah.

SAC ACCP was established in 2006. It all started with the ACCP board of regents under the leadership of Dr. Lawrence Lesko (ex president of ACCP), proposing at the meeting in March 2005, to explore setting up international chapters. Dr. Chandrahas Sahajwalla, then chair of the Membership committee for ACCP took the lead in identifying qualified scientists in India with passion and drive to promote Clinical Pharmacology and the principles and values of ACCP. On March 14, 2005 Dr. Sahajwalla invited Dr.

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ABOUT AUTHORS:
Rajmahamad H. Shaikh¹*, Mohsin J. Jamadar¹, Amol D. Patil¹, Audumbar D. Mali², Sanauaha M.Tamboli^1
1Department of Pharmaceutics, Appasaheb Birnale college of Pharmacy, Sangali, Maharashtra, India.
²Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India
rajshaikh71@gmail.com

ABSTRACT:
The purpose of this investigation was to enhancement of solubility of cinnarizine by using solid dispersion technique solvent evaporation method using polymer PEG 6000 & develop combination ODT of cinnarizine with domperidone by using direct compression technique using crospovidone, croscarmellose sodium and sodium starch glycolateas a superdisintegrants. The preformulation study includes the compatability of drugs with the polymers by using FTIR,UV,TLC. The batches were evaluated for weight variation, hardness, friability, drug content, wetting time, IN In-vitro dispersion, in-vitro dissolution. The formulation F2 which contain 8% crospovidone and 10 % sodium starch glycolate showed best results and rapid in-vitro dissolution. The results revealed that the tablets containing superdisintegrants combination had a good dissolution profile. The drug content of all the batches was within the acceptable limits of the United States Pharmacopoeia with maximum drug being released at all timeintervals. The present study demonstrated potentials for rapidabsorption, improved bioavailability, effective therapy and patientcompliance. The results conclusively demonstrate successful enhancement of solubility, disintegration and dissolution of the formulated tablets.