July 2012

About Authors:
ATUL KABRA^* , PREMAL KAPADIA
Department of Pharmacology,
G.H.B Pharmacy college,
Aniyad, Gujarat
* atul.kbr@gmail.com

ABSTRACT:
The cardiovascular risk factors were significantly abnormally altered in diabetic rats when compared to normal control. The present study FLEt with low dose of OHA’s indicates the significant improvement in endothelial dependent vasodilatation because the percentage relaxation produced by acetylcholine was more significant when these groups were compared with diabetic control.However all the treated groups restored these changes significantly to normal conditions in diabetic rats when compared to diabetic control. The combined therapy of FLEt and Fluvastatin was found to be significantly effective. Moreover, this combination was also found to demonstrate synergistic behavior than pioglitazone plus fluvastatin.
We conclude that of preventive therapy with combination of FLEt with OHA’s (low dose) may prevent the endothelial dysfunction in diabetic patients (prediabetic state) due to free radical scavenging activity, metabolic control.

About Authors:
¹Shashi Kant^*, Satinder Kumar,
Research Scholar Department of Pharmacy.
²Dr. Bharat Prashar
HOD & Associate professor,
Department of Pharmaceutical Sciences,
Manav Bharti University, Solan (H.P)
* shashi_ranaute@yahoo.in

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