November 2011

Women's Healthcare Division (WHD) offers whole range of women healthcare products, which provide total healthcare for women of all ages-addressing their social, mental and physical well being.
WHD's product basket includes highly innovative prescription products viz Contraceptives, Ovulation Inducers, Antiemetics, Menstural Cycle Regulators, Antifibrinolytics, MTP Pills, Pregnancy Test Kits, Natural Products and Vaccines.

Zydus Cadila is a professionally managed public company offering immense opportunities to learn and grow. This ability to evolve, gain new capabilities and raise the bar of excellence forms the heart of our success. We provide an environment where people come and give their best not because they have to, but because they want to. At Zydus we build people to build our business.

Health and well-being with the power of nature, that is the foundation of Sanat Products Limited, an enterprise dedicated to promoting life and health through the goodness of natural products. Sanat stands for sa - auspicious and nat - natural. Their concern for nature is also manifest in their distinctive logo symbolising the green earth and blue sky, constantly renewing each other in an eternal cycle.

About Authors:
Tarun Garg, Ajay Bilandi,
Seth G.L.Bihani S.D.college of technical education,
Sri Ganganagar

ABSTRACT
The aim of this review is to improve the solubilization and bioavailability of poorly soluble drugs by using various approaches like physical, chemical and others modifications or techniques. The solubility of a solute is the maximum quantity of solute that can dissolve in a certain quantity of solvent or quantity of solution at a specified temperature. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Drug efficacy can be severely limited by poor aqueous solubility and some drugs also show side effects due to their poor solubility. There are many techniques which are used to enhance the aqueous solubility. The ability to increase aqueous solubility can thus be a valuable aid to increasing efficiency and/or reducing side effects for certain drugs. This is true for parenterally, topically and orally administered solutions. Physical modifications techniques like media milling/ nanocrystal technology, cryogenic technology, supercritical fluid process, modification of the crystal habit,complexation, micellar technologies, chemical modifications, other techniques like co-crystallization, cosolvency, hydrotrophy are used for increase the solubility of very soluble drugs like dolargin, loperamide, tubocurarine, doxorubicin, ibuprofen, griseofulvin, diazepam, naproxen, carbamazepine, nifedipine, phytosterol etc.

About Authors:
Ratnadeep V. Ghadage (M. Pharmacy)
Department of Pharmaceutical Chemistry,
Appasaheb Birnale College of Pharmacy,
South Shivaji Nagar, Sangli-416416,
Maharashtra

ABSTRACT:
Quinoxaline derivatives have emerged as an important class of benzoheterocycles because of their diverse pharmacological and biological properties, which make them privileged structures in combinatorial drug discovery libraries. Also Quinoxaline derivatives constitute useful intermediates in organic synthesis. The pharmaco-logical importance of quinoxalines and their utility as building blocks in organic synthesis have directed considerable research activities toward the synthesis of suitably substituted quinoxaline rings. Extensive researches have generated numerous synthetic approaches for the construction of the skeleton of such heterocycles. Quinoxalines are, in general, comparatively easy to prepare, and numerous derivatives have been designed and prepared for potential use as biologically active materials. Oxidation of both nitrogen of the quinoxaline ring dramatically increases the diversity of certain biological properties.
Quinoxalines, including their fused-ring derivatives, display diverse pharmacological activities.A number of synthetic strategies have been developed for the preparation of substituted quinoxalines. The classical synthesis of quinoxalines involves the condensation of an aromatic 1, 2-diamine with a 1, 2-dicarbonyl compound. The reaction is facile and is the most widely used synthetic method for both quinoxaline itself and its derivatives. Despite remarkable efforts,the development of an effective method for the synthesis of quinoxalines is still an important challenge.

HLL Lifecare Limited is a Mini Ratna Company of Govt. of India under the Ministry of Health & Family Welfare. HLL, a schedule B Public Sector Enterprise is today a multi product, multi unit organization addressing various public health challenges. The company with five manufacturing units and marketing offices throughout the country is engaged in the manufacturing and marketing of a wide range of contraceptives and healthcare products.

IIT Bombay, set up by an Act of Parliament, was established in 1958, at Powai, a northern suburb of Mumbai. Today the Institute is recognised as one of the centres of academic excellence in the country.