Monthly archive | PharmaTutor

15 April 2011

Effect of curcumin (Curcuma longa, Zingiberaceae) against sciatic nerve ligation induced behavioral and biochemical alterations: Possible involvement of nitric oxide mechanism

About Authors: Seema Meena, Anil Kumar and Shikha Chauhan
a) Amity Institute of Pharmacy, Amity University, Noida,-201301, India.
b) Neuropharmacology division, University Institute of Pharmaceutical Sciences, UGC Centre for Advance Studies, Panjab University, chandigarh-160014, India.

Abstract:
Neuropathic pain represents a real clinical challenge because of its severity, chronic nature, and inadequate drug therapy. Recently, nitric oxide pathway has been proposed in the pathogenesis neuropathic pain like conditions. Curcumin is a well known for its antioxidant and medicinal values. The objective of the present study was to explore possible nitric oxide mechanism in the protective effect of curcumin against sciatic nerve ligation induced behavioral and biochemical alterations in rats.Sciatic nerve ligation was performed in Wistar rats. Various behavioral parameters (thermal hyperalgesia, cold allodynia) followed by assessment of biochemical parameters (lipid peroxidation, reduced glutathione, catalase, and nitrite) both on sciatic nerves and brain. Sciatic nerve ligation significantly caused thermal hyeralgesia, cold allodynia and oxidative damage as compared to sham (Sciatic nerve without ligation) and naïve animals. Chronic administration of curcumin (20 mg/kg, po) significantly reversed behavioral alteration and attenuated oxidative damage in both sciatic nerve and brain as compared to control. Further, L-NAME (5 mg/kg) pretreatment with curcumin (10 mg/kg, po) potentiated protective effect of curcumin as compared to their effect per se. However, L-arginine (100 mg/kg) pretreatment with curcumin (10 mg/kg, po) significantly reversed the protective effects of curcumin. Result of present study suggests that nitric oxide mechanism could be involved in the protective effect of curcumin against sciatic nerve ligation induced behavior and biochemical alterations in rats.

15 April 2011

Overview and Information of BENFOTIAMINE

About Author: Sayani Chakrabarti
M.Pharm in Pharmaceutical Chemistry
SIPS, Jharpokharia
Mayurbhanj-757086
Orissa

ABSTRACT
Benfotiamine (rINN, or S-benzoylthiamine O-monophoshate) is a synthetic S-acyl derivative of thiamine (vitamin B1). It has potential anti oxidant effect. A three-armed, randomized, multicentre, placebo-controlled double-blind study was used to examine the efficacy of benfotiamine vs a combination containing benfotiamine and vitamins B6 and B12 in out-patients with severe symptoms of alcoholic polyneuropathy (Benfotiamine in treatment of Alcoholic Polyneuropathy. BAP I). The study period was 8 weeks and 84 patients fulfilled all the prerequisite criteria and completed the study as planned. Benfotiamine led to significant improvement of alcoholic polyneuropathy. Vibration perception (measured at the tip of the great toe) significantly improved in the course of the study, as did motor function, and the overall score reflecting the entire range of symptoms of alcoholic polyneuropathy. A tendency toward improvement was evident for pain and co-ordination, no therapy-specific adverse effects were seen.

14 April 2011

Multiple Vacancies in Stedman Pharmaceuticals in production, PMT, Sales Departments

Stedman is a dynamic, fast growing, ethical, systematic & marketing oriented co. with a vision of becoming a force to reckon within the pharmaceutical industry & known for its successful introduction of innovative concepts/products in various segments.

14 April 2011

Require PSR, ABM, PBM in Ind-Swift

One of the leading R&D driven 1600 CR. PHARMA GROUP of India having presence across 45 countries, having established brands like ANIN / VORANIN / CLARIE / FEXIDINE / INDCEF / SUPROX / DISTONE / TOSS / STEMIN / NETAZOX.
In its major expansion plan, invites applications from Energetic & Result Oriented personnel for various Field Sales Profiles, For its Divisions: GYNOSWIFT / MEGASWIFT / CARD IASWI FT / Q-DEN / ONCRIT.

14 April 2011

Vacancy in Bioanalytical and QA departments at Accutest Research Laboratories - Total 26 vacancies: Mumbai, Mexico, Ahmedabad | Freshers can also apply.

14 April 2011

Officer, Executive Q.A, Q.C & Prod. Require in Rajat Pharmachem Ltd.

Rajat Pharmachem Ltd. is a Formulation plant located at Ankleshwar, Bharuch - Dist, Gujarat. The company is engaged in the manufacturing of formulation like Tablets, Capsules, Oral Powder & Effervescent Tablet.
The the company is WHO-GMP, NAFDAC - Nigeria, FDB Ghana, ISO 9001:2008, ISO 22000:2005 approved company.
The company is having vast range of tablets, capsules, powder and lataste technology of effervescent tablet manufacturing.

14 April 2011

Job in Thomson Reuters as Associate Research Analyst - Biosis

Thomson Reuters is the leading source of intelligent information for the world's businesses and professionals, providing customers with competitive advantage.

14 April 2011

The Scienomics Group (TSG) require VP, Group Account Director

The Scienomics Group (TSG) is a full-service communications company based in Greenwich, CT, with offices in New York and San Francisco that provides medical education services globally to support pharmaceutical products and devices/diagnostics throughout a product’s lifecycle. Services offered by TSG include scientific message development, gap analyses, strategic planning, publications and program planning and implementation, live events, speakers’ bureau, and much more.

14 April 2011

Job as a Medical Representative / Territory Manager - East Region at Wallace Pharmaceuticals Pvt. Ltd.

Wallace Pharmaceuticals is a progressive, professionally managed and growing pharmaceutical company with a special focus on Antibiotic, Anti -infective, Analgesic, Anti-inflammatory, Antiacne, Paediatric, Orthopaedic, Dermatology and Diabetic segments.

Post: Medical Representative

14 April 2011

Work as a Medical Representative - South Zone @ ICPA Health Products Ltd. - 4 Openings

Based in Mumbai ICPA operates throughout India, Nepal, Srilanka, Bangladesh, Yemen, Myanmar and Malaysia and is working at an accelerated pace to start operations in many other countries in the near future.
ICPA, the leaders in Oral Health Care has also got specialized Herbal & Cosmetic products and is presently looking for areas of further growth and expansion.