Mechanism Of Action of Atropine
Atropine and other muscarinic antagonists are competitively binds to receptors with Ach or other agonists. Muscarinic receptors are GPCRs. They have 7-helical amino acid structure, the aspartate present on the –NH2 end of the receptor. This form link between agonist/antagonist with the receptor. If concentration of Ach is increased, effect of antagonist overcomes. But chE antagonist along with M-antagonist works in right way.
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