The Institute of Cancer Research (a College of the University of London) is a world-class cancer research organisation. The Section of Structural Biology at ICR is exceptionally well equipped for all aspects of modern structural biology, with state-of-the-art laboratories for molecular biology, recombinant expression in bacterial and eukaryotic systems, biochemistry, X-ray crystallography and electron microscopy. Excellent synchrotron access (~ 2 days per month) is available through rolling beam allocation programmes at Diamond and ESRF.
Structural Biology of proteins involved in DNA repair
Postdoctoral positions are available to join a team in the laboratory of Professor Dale Wigley, FRS, who has recently relocated to the Institute of Cancer Research.
The project will be to study the structure and mechanism of proteins involved in DNA double-strand break repair, a key aspect in the prevention of cancers. Studies will include the bacterial RecBCD and AddAB complexes as well as the human DNA double-strand break repair complexes, several of which are already expressed and purified. The postholder/s will join a team of international scientists with a diverse range of structural and biochemical expertise working closely together and will be responsible for expression, purification, crystallization and structural analysis of proteins and protein complexes either by crystallography or electron microscopy.
Applicants should hold a PhD in a biological, chemical or physical science, have experience of macromolecular crystallography and recombinant protein expression, and evidence of a good publication record. Experience in determining structures by MIR or MAD, or of single particle electron microscopy would be an advantage.
The starting salary will be in the range £26,996 to £32,024 p.a. inclusive (based on previous post-doctoral experience) and posts will be offered on 3 year fixed term contracts initially.
Informal enquiries can be made to Professor Dale Wigley (Dale.Wigley@icr.ac.uk). Please note – this address is for enquiries ONLY and CVs must be submitted in line with the instructions below.
To apply please email your CV and covering letter (addressing where you meet the person specification and incl. the names and addresses of two referees) to: recruitment@icr.ac.uk quoting job reference number C370.
In a separate email, please send your completed equal opportunities monitoring form http://www.icr.ac.uk/jobs/current_vacancies/4959.doc to the same email address quoting the job reference number above.
Closing date: 31st October 2010
See All Ph.D Alerts M.Pharm Alerts
See All Other Jobs in our Database
.png)
