Beatson, as one of Cancer Research UK’s core-funded institutes, carry out a programme of world-class science directed at understanding key aspects of cancer cell behaviour, and try to translate these discoveries into new therapies and diagnostic/prognostic tools to help cancer patients. The Institute benefits from close interactions with the University of Glasgow, including strong links with the University’s Institute of Cancer Sciences.
Post: Postdoctoral Fellows
Rab-coupling protein (RCP)-mediated receptor trafficking in breast cancer progression {below}
Cancer Invasion and Metastasis
Tumour Related Inflammation in Drosophila
Rab-coupling protein (RCP)-mediated receptor trafficking in breast cancer progression:
Funded by Breast Cancer Campaign
Starting Salary from £28500 - £38000 pa (depending on experience).
3 year fixed term contract
You will study the role of receptor trafficking in mammary carcinogenesis by deploying a newly generated genetically-engineered (GEM) model with mammary-specific knockout of a key Rab GTPase effector, RCP. This will include the isolation and culture of primary tumour cells allowing the implementation of a novel SILAC mass spectrometry approach to define the RCP ‘recyclome' in breast cancer. In addition, the project will contain a substantial amount of live cell imaging to enable the visualisation of RCP's contribution to trafficking of integrins, HER2 and other receptors during metastasis. (J. Cell Biol. 183:143; Cell 139:1327; Nat. Rev. Mol. Cell Biol. 10:843)
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A relevant PhD is essential and experience in cell biology/biochemistry, in vivo biology and/or live cell imaging would be an advantage. Applications with CV and names of three referees should be sent to Prof. JC Norman,The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK. Email j.norman@beatson.gla.ac.uk. Informal inquiries should be directed to Dr Norman or to Dr Iain Macpherson (iain.macpherson@glasgow.ac.uk).
Closing Date: 21 Spetember 2012
Cancer Invasion and Metastasis:
Starting Salary from £28,500 - £38,000 pa (depending on experience).
3 year fixed term contract
Melanoma cells are uniquely highly migratory and this is thought to originate from their embryonic state as singly migrating mesenchymal cells and contribute to the metastatic nature of this cancer. Our group aims to understand basic molecular mechanisms driving cell migration and invasion and to apply this to understanding how melanoma cells invade and metastasise. We also study the migration of melanoblasts, the normal melanocyte precursor cells, using in vivo and ex vivo methods. You will join a team actively investigating the regulation of cell migration by Rho-family GTPases, Arp2/3 complex and WASP-family proteins and the complex interactions of normal melanoblasts/cytes and melanoma cells within the context of the skin. We aim to identify key nodes in the actin assembly machinery as potential targets against melanoma metastasis and fundamental mechanisms governing migration.
You must have a relevant Ph.D. in molecular cell biology or murine genetics and experience with imaging and microscopy would be an advantage. You must be enthusiastic and motivated to work both with in vivo and cellular models.
Applications with CV and names of three referees should be sent either by post or E-mail to Prof. Laura Machesky, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK. Email l.machesky@beatson.gla.ac.uk.
closing Date: 21 September 2012
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Tumour Related Inflammation in Drosophila:
Starting Salary from £28500 - £38000 pa (depending on experience).
3 year fixed term contract
You will join a team carrying out research to understand how tumour associated inflammation promotes tumour malignancy or death in different contexts. The reseach will analyse the role of the genetic background and cell poloarity in tumour progression. The effects of tumour development will be assessed both in the tumour microenviromnet and systematically. You will become part of a team using Drosophilla genetics and advanced confocal microscopy techniques.
A relevant PhD is essential and experience in genetics and imaging techniques would be an advantage.
Applications with CV and names of three referees should be sent to Dr Marcos Vidal, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK, by email to m.vidal@beatson.gla.ac.uk
Closing Date: 23 September 2012
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