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Pharmatutor Sample Paper 1

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                                       SAMPLE PAPER-1

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MEDICINAL CHEMISTRY
 

   1. Pyrimethacine is derivative of
         1. Pyridine
         2. Pyrimidine
         3. Acridine
         4. None of above

       
   2. Tolazoline is derivative of
         1. 4,5-diydroimidazole
         2. 2-imidazolidinedione
         3. 5-imidazole
         4. Pyrazolidinedione

       
   3. Oxyphencyclamine is synthesized from

         1. α-cyclohexyl-α-hydroxy-α-phenyl acetic acid
         2. α-propionyl-p-chlorophenyl aceto nitrile
         3. α-benzyl- α-methyl-p-hydroxy acetic acid
         4. a & b

       
   4. Pentetrazol contains,
         1. 4 membered ring
         2. 4 double bonds
         3. Azepine nucleus
         4. Diazepine nucleus

       
   5. Van Braun’s method for opening of tetracyclic amines involves treatment of compound with

         1. HCN
         2. BrCN
         3. ICI
         4. CN-CH2-COOH

       
   6. Reserpine on hydrolysis gives
         1. Reserpic acid + Methyl alcohol + Trimethoxycinnamic acid
         2. Reserpic acid + Acetic acid + Trimethoxybenzaldehyde
         3. Reserpic acid + Methyl alcohol + Trimethoxybenzoic acid
         4. Reserpic acid + Methyl alcohol + Trimethoxycinnamaldehyde

       
   7. The factors affecting diffusion current in polarography can be given by which of following,

         1. Nernst equation
         2. Mark-Houwink equation
         3. Lamberts law
         4. Ilkovic equation

       
   8. Thiotepa, a cytotoxic agent, is assay by titrating with
         1. HCl
         2. HClO4
         3. Na2S2O3
         4. KMnO4

       
   9. IUPAC name of Pethidine is,
         1. RS-dimethyl[1-phenyl-3-(phenothiazin-10-yl)propyl]amine
         2. Ethyl-1-methyl-4-phenyl-piperidine-carboxylate
         3. RS-1-isopropylamino-3-(1-nephthyloxy)-propon-2-ol
         4. Propyl-4-carbamoylmethoxy-3-methoxy-phenyl acetate

       
  10. The chemical reaction shown below can be carried out using following reagent,        

a.       AlCl3
b.      CuCl2
c.       CH3COONa
d.      CH3MgBr

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                                   Answers are at the end of the sample paper.