SAMPLE PAPER-1
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MEDICINAL CHEMISTRY
1. Pyrimethacine is derivative of
1. Pyridine
2. Pyrimidine
3. Acridine
4. None of above
2. Tolazoline is derivative of
1. 4,5-diydroimidazole
2. 2-imidazolidinedione
3. 5-imidazole
4. Pyrazolidinedione
3. Oxyphencyclamine is synthesized from
1. α-cyclohexyl-α-hydroxy-α-phenyl acetic acid
2. α-propionyl-p-chlorophenyl aceto nitrile
3. α-benzyl- α-methyl-p-hydroxy acetic acid
4. a & b
4. Pentetrazol contains,
1. 4 membered ring
2. 4 double bonds
3. Azepine nucleus
4. Diazepine nucleus
5. Van Braun’s method for opening of tetracyclic amines involves treatment of compound with
1. HCN
2. BrCN
3. ICI
4. CN-CH2-COOH
6. Reserpine on hydrolysis gives
1. Reserpic acid + Methyl alcohol + Trimethoxycinnamic acid
2. Reserpic acid + Acetic acid + Trimethoxybenzaldehyde
3. Reserpic acid + Methyl alcohol + Trimethoxybenzoic acid
4. Reserpic acid + Methyl alcohol + Trimethoxycinnamaldehyde
7. The factors affecting diffusion current in polarography can be given by which of following,
1. Nernst equation
2. Mark-Houwink equation
3. Lamberts law
4. Ilkovic equation
8. Thiotepa, a cytotoxic agent, is assay by titrating with
1. HCl
2. HClO4
3. Na2S2O3
4. KMnO4
9. IUPAC name of Pethidine is,
1. RS-dimethyl[1-phenyl-3-(phenothiazin-10-yl)propyl]amine
2. Ethyl-1-methyl-4-phenyl-piperidine-carboxylate
3. RS-1-isopropylamino-3-(1-nephthyloxy)-propon-2-ol
4. Propyl-4-carbamoylmethoxy-3-methoxy-phenyl acetate
10. The chemical reaction shown below can be carried out using following reagent,
a. AlCl3
b. CuCl2
c. CH3COONa
d. CH3MgBr
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Answers are at the end of the sample paper.